Journal article
The contributory role of vascular health in age-related anabolic resistance
Journal of cachexia, sarcopenia and muscle, Vol.13(1), pp.114-127
02/2022
DOI: 10.1002/jcsm.12898
PMCID: PMC8818606
PMID: 34951146
Abstract
Sarcopenia, or the age-related loss of skeletal muscle mass and function, is an increasingly prevalent condition that contributes to reduced quality of life, morbidity, and mortality in older adults. Older adults display blunted anabolic responses to otherwise anabolic stimuli-a phenomenon that has been termed anabolic resistance (AR)-which is likely a casual factor in sarcopenia development. AR is multifaceted, but historically much of the mechanistic focus has been on signalling impairments, and less focus has been placed on the role of the vasculature in postprandial protein kinetics. The vascular endothelium plays an indispensable role in regulating vascular tone and blood flow, and age-related impairments in vascular health may impede nutrient-stimulated vasodilation and subsequently the ability to deliver nutrients (e.g. amino acids) to skeletal muscle. Although the majority of data has been obtained studying younger adults, the relatively limited data on the effect of blood flow on protein kinetics in older adults suggest that vasodilatory function, especially of the microvasculature, strongly influences the muscle protein synthetic response to amino acid feedings. In this narrative review, we examine evidence of AR in older adults following amino acid and mixed meal consumption, examine the evidence linking vascular dysfunction and insulin resistance to age-related AR, review the influence of nitric oxide and endothelin-1 on age-related vascular dysfunction as it relates to AR, briefly review the potential causal role of arterial stiffness in promoting skeletal muscle microvascular dysfunction and AR, and provide a brief overview and future considerations for research examining age-related AR.
Details
- Title: Subtitle
- The contributory role of vascular health in age-related anabolic resistance
- Creators
- Nile F Banks - University of IowaEmily M Rogers - University of IowaDavid D Church - University of Arkansas for Medical SciencesArny A Ferrando - University of Arkansas for Medical SciencesNathaniel D M Jenkins - Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of cachexia, sarcopenia and muscle, Vol.13(1), pp.114-127
- DOI
- 10.1002/jcsm.12898
- PMID
- 34951146
- PMCID
- PMC8818606
- NLM abbreviation
- J Cachexia Sarcopenia Muscle
- ISSN
- 2190-5991
- eISSN
- 2190-6009
- Grant note
- 18AIREA33960528 / American Heart Association-American Stroke Association NIH HHS
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259643502771
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