Journal article
The cortical structure of functional networks associated with age-related cognitive abilities in older adults
PloS one, Vol.13(9), pp.e0204280-e0204280
2018
DOI: 10.1371/journal.pone.0204280
PMCID: PMC6150534
PMID: 30240409
Abstract
Age and cortical structure are both associated with cognition, but characterizing this relationship remains a challenge. A popular approach is to use functional network organization of the cortex as an organizing principle for post-hoc interpretations of structural results. In the current study, we introduce two complimentary approaches to structural analyses that are guided by a-priori functional network maps. Specifically, we systematically investigated the relationship of cortical structure (thickness and surface area) of distinct functional networks to two cognitive domains sensitive to age-related decline thought to rely on both common and distinct processes (executive function and episodic memory) in older adults. We quantified the cortical structure of individual functional network's predictive ability and spatial extent (i.e., number of significant regions) with cognition and its mediating role in the age-cognition relationship. We found that cortical thickness, rather than surface area, predicted cognition across the majority of functional networks. The default mode and somatomotor network emerged as particularly important as they appeared to be the only two networks to mediate the age-cognition relationship for both cognitive domains. In contrast, thickness of the salience network predicted executive function and mediated the age-cognition relationship for executive function. These relationships remained significant even after accounting for global cortical thickness. Quantifying the number of regions related to cognition and mediating the age-cognition relationship yielded similar patterns of results. This study provides a potential approach to organize and describe the apparent widespread regional cortical structural relationships with cognition and age in older adults.
Details
- Title: Subtitle
- The cortical structure of functional networks associated with age-related cognitive abilities in older adults
- Creators
- Michael B Kranz - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States of AmericaMichelle W Voss - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, United States of AmericaGillian E Cooke - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States of AmericaSarah E Banducci - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States of AmericaAgnieszka Z Burzynska - Department of Human Development and Family Studies/ Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, United States of AmericaArthur F Kramer - Departments of Psychology and Mechanical and Industrial Engineering, Northeastern University, Boston, MA, United States of America
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.13(9), pp.e0204280-e0204280
- DOI
- 10.1371/journal.pone.0204280
- PMID
- 30240409
- PMCID
- PMC6150534
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- R01 AG036682 / NIA NIH HHS
- Language
- English
- Date published
- 2018
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002431002771
Metrics
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