Journal article
The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins
Cell, Vol.65(2), pp.219-227
1991
DOI: 10.1016/0092-8674(91)90156-S
PMID: 1707759
Abstract
Mutations in the Drosophila
ninaA gene cause dramatic reductions in rhodopsin levels, leading to Impaired visual function. The ninaA protein is a homolog of peptidyl-prolyl
cis-trans isomerases. We find that ninaA is unique among this family of proteins in that it is an integral membrane protein, and it is expressed in a cell type-specific manner. We have used transgenic animals misexpressing different rhodopsins in the major class of photoreceptor cells to demonstrate that
ninaA is required for normal function by two homologous rhodopsins, but not by a less conserved member of the Drosophila rhodopsin gene family. This demonstrates in vivo substrate specificity in a cyclophilin-like molecule. We also show that vertebrate retina contains a ninaA-related protein and that
ninaA is a member of a gene family in Drosophila. These data offer insights into the in vivo role of this important family of proteins.
Details
- Title: Subtitle
- The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins
- Creators
- Mark A. Stamnes - Howard Hughes Medical InstituteBih-Hwa Shieh - Howard Hughes Medical InstituteLorraine Chuman - Howard Hughes Medical InstituteGreg L. Harris - Howard Hughes Medical InstituteCharles S. Zuker - Howard Hughes Medical Institute
- Resource Type
- Journal article
- Publication Details
- Cell, Vol.65(2), pp.219-227
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0092-8674(91)90156-S
- PMID
- 1707759
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 1991
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297610402771
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