Journal article
The cytoplasmic and transmembrane domains of MHC class II β chains deliver distinct signals required for MHC class II-mediated B cell activation
Immunity (Cambridge, Mass.), Vol.3(3), pp.349-358
1995
DOI: 10.1016/1074-7613(95)90119-1
PMID: 7552999
Abstract
Class II-mediated signals play potential roles in B cell activation and antigen presentation. The regions of the class II molecule participating in B cell signaling are incompletely defined. Our prior analysis of structural requirements of the cytoplasmic domain of A
β revealed that only the eight membrane-proximal residues are required for signaling. Here, we report that the sequence and position of two of these are critical, and present direct evidence that the A
β transmembrane domain is also involved in signaling, via a pathway distinct from the cytoplasmic domain. These results demonstrate that specific regions in both the cytoplasmic and transmembrane domains of the class II molecule have distinct signaling functions.
Details
- Title: Subtitle
- The cytoplasmic and transmembrane domains of MHC class II β chains deliver distinct signals required for MHC class II-mediated B cell activation
- Creators
- Jonathan A Harton - Department of Microbiology University of Iowa Iowa City, Iowa 52242, USAAmy E Van Hagen - Department of Microbiology University of Iowa Iowa City, Iowa 52242, USAGail A Bishop - Department of Microbiology University of Iowa Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.3(3), pp.349-358
- Publisher
- Elsevier Inc
- DOI
- 10.1016/1074-7613(95)90119-1
- PMID
- 7552999
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 1995
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001223002771
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