Journal article
The development of depressive symptoms during medical internship stress predicts worsening vascular function
Journal of psychosomatic research, Vol.79(3), pp.243-245
09/2015
DOI: 10.1016/j.jpsychores.2015.06.004
PMCID: PMC4522220
PMID: 26115588
Abstract
We sought to prospectively determine whether the onset of internship stress and any subsequent depression alters physiological markers of early vascular disease
We explored potential mechanisms linking stress and depression to vascular disease in a prospective cohort of 37 participants exposed to medical internship stress, an established precipitant of depressive symptomatology.
Change in depressive symptom score from baseline over one year of internship stress was inversely correlated with change in the reactive hyperemia index (RHI), a measure of peripheral endothelial function (r=0.41, p=0.01). The change in depressive symptoms in the first six months of internship was similarly related to change in RHI over one year (r=0.38, p=0.02). While the development of depressive symptoms did not significantly impact changes in endothelial progenitor cells (EPCs), EPCs did significantly decrease with the year of internship stress (11.9 to 3.4cells/ml blood; p=0.01).
Endothelial function may be a critical link between stress, depression, and cardiovascular disease and a feasible surrogate outcome for prospective studies.
•We assessed vascular function in a prospective cohort of medical interns.•The development of depressive symptoms predicted worse endothelial function.•Endothelial progenitor cells were lower after one year of chronic stress.•Endothelial function may link stress, depression, and cardiovascular disease.
Details
- Title: Subtitle
- The development of depressive symptoms during medical internship stress predicts worsening vascular function
- Creators
- Jess G Fiedorowicz - Department of Psychiatry, The University of Iowa, Iowa City, IA, United StatesVicki L Ellingrod - College of Pharmacy, University of Michigan, Ann Arbor, MI, United StatesMariana J Kaplan - Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United StatesSrijan Sen - Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
- Resource Type
- Journal article
- Publication Details
- Journal of psychosomatic research, Vol.79(3), pp.243-245
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpsychores.2015.06.004
- PMID
- 26115588
- PMCID
- PMC4522220
- ISSN
- 0022-3999
- eISSN
- 1879-1360
- Grant note
- DOI: 10.13039/100000025, name: NIMH, award: R01 MH101459, K23 MH095109; DOI: 10.13039/100008269, name: Michigan Institute for Clinical and Health Research, award: UL1RR024986; DOI: 10.13039/100000025, name: NIMH, award: K23 MH083695; DOI: 10.13039/100000050, name: NHLBI, award: P01HL014388; DOI: 10.13039/100000025, name: NIMH, award: R01 MH082784
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute
- Record Identifier
- 9984070658302771
Metrics
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