The development of the hindbrain afferent projections in the axolotl: Evidence for timing as a specific mechanism of afferent fiber sorting

Bernd Fritzsch; Darin Gregory; Eduardo Rosa-Molinar

doi:10.1016/j.zool.2005.08.003

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The development of the hindbrain afferent projections in the axolotl: Evidence for timing as a specific mechanism of afferent fiber sorting

Journal article

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The development of the hindbrain afferent projections in the axolotl: Evidence for timing as a specific mechanism of afferent fiber sorting

Bernd Fritzsch, Darin Gregory and Eduardo Rosa-Molinar

Zoology (Jena), Vol.108(4), pp.297-306

2005

DOI: 10.1016/j.zool.2005.08.003

PMCID: PMC3918876

PMID: 16351978

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Abstract

The aim of this study is to reveal the timing and growth pattern of central octavolateral projection development in the Mexican axolotl,\nAmbystoma mexicanum. In this amphibian species the development of the inner ear occurs first, followed by mechanosensory lateral line organs, and finally by ampullary electroreceptors. Several hypotheses have been proposed about how the development of peripheral organs, including differential projections of the ear, might relate to the development of central projections. Our data suggest that the sequence of maturation of the ear, mechanosensory lateral line, and ampullary electroreceptive organs is closely accompanied by the timed development of the trigeminal, inner ear, mechanosensory lateral line organs, and the ampullary electroreceptor afferent projections in the axolotl. Our data suggest that segregation of central termination within the alar plate is a function of time and space: later forming organs are likely innervated by later forming ganglia that project centrally later and to more dorsal areas of the alar plate that have not yet received any other afferents. Later forming ganglia of the same type may grow along existing pathways of earlier formed neurons.

Central projection

Ampullary organ

Ambystoma mexicanum

Electroreception

Afferent

Details

Title: Subtitle: The development of the hindbrain afferent projections in the axolotl: Evidence for timing as a specific mechanism of afferent fiber sorting
Creators: Bernd Fritzsch - Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
Darin Gregory - Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA
Eduardo Rosa-Molinar - Julio Garcia Center for Investigations in Biology, University of Puerto Rico-Rio Piedras, San Juan, PR, 00931-1809, Puerto Rico, USA
Resource Type: Journal article
Publication Details: Zoology (Jena), Vol.108(4), pp.297-306
DOI: 10.1016/j.zool.2005.08.003
PMID: 16351978
PMCID: PMC3918876
NLM abbreviation: Zoology (Jena)
ISSN: 0944-2006
eISSN: 1873-2720
Publisher: Elsevier GmbH
Language: English
Date published: 2005
Academic Unit: Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
Record Identifier: 9984070117702771

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