Journal article
The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation
Neuropharmacology, Vol.94, pp.58-63
07/2015
DOI: 10.1016/j.neuropharm.2014.12.013
PMCID: PMC4458430
PMID: 25582293
Abstract
Chronic muscle pain affects between 11 and 24% of the world's population with the majority of people experiencing musculoskeletal pain at some time in their life. Acid sensing ion channels (ASICs) are important sensors of modest decreases in extracellular pH that occur within the physiological range. These decreases in extracellular pH occur in response to inflammation, fatiguing exercise, and ischemia. Further, injection of acidic saline into muscle produces enhanced nociceptive behaviors in animals and pain in human subjects. Of the different types of ASICs, ASIC3 and ASIC1 have been implicated in transmission of nociceptive information from the musculoskeletal system. The current review will provide an overview of the evidence for ASIC3 and ASIC1 in musculoskeletal pain in both inflammatory and non-inflammatory models. This article is part of the Special Issue entitled 'Acid-Sensing Ion Channels in the Nervous System'.
Details
- Title: Subtitle
- The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation
- Creators
- Kathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, IA 52242, USA. Electronic address: kathleen-sluka@uiowa.eduNicholas S Gregory - Department of Physical Therapy and Rehabilitation Science, Neuroscience Graduate Program, Pain Research Program, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neuropharmacology, Vol.94, pp.58-63
- DOI
- 10.1016/j.neuropharm.2014.12.013
- PMID
- 25582293
- PMCID
- PMC4458430
- NLM abbreviation
- Neuropharmacology
- ISSN
- 0028-3908
- eISSN
- 1873-7064
- Publisher
- England
- Grant note
- R01 AR052316 / NIAMS NIH HHS T32 NS045549 / NINDS NIH HHS AR061371 / NIAMS NIH HHS AR063381 / NIAMS NIH HHS T32 GM007337 / NIGMS NIH HHS R01 AR061371 / NIAMS NIH HHS UM1 AR063381 / NIAMS NIH HHS R01 AR053509 / NIAMS NIH HHS
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040393702771
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