Journal article
The effect of alendronate on fracture-related healthcare utilization and costs: the fracture intervention trial
Osteoporosis international, Vol.12(8), pp.654-660
2001
DOI: 10.1007/s001980170065
PMID: 11580079
Abstract
The Vertebral Fracture Arm (VFA) of the Fracture Intervention Trial (FIT) study demonstrated that alendronate reduced the incidence of spine, forearm and hip fractures in women with low bone mass and existing vertebral fractures by about 50%. The objective of the present study was to determine the effects of alendronate therapy versus placebo on fracture-related healthcare utilization and costs. Participants were randomly assigned to double-masked treatment with alendronate (5 mg/day for 2 years and then 10 mg/day for 1 year) or placebo for 3 years. For each patient experiencing a clinical fracture, we determined whether treatment in an emergency room, hospital, nursing home and/or rehabilitation hospital was a consequence of the fracture. The VFA of the FIT Study enrolled 2027 women aged 55-81 years with low bone mass and pre-existing vertebral fractures from population-based listings in 11 metropolitan areas of the United States. We measured (1) the proportion of patients who had any fracture-related healthcare event and (2) the estimated cost of fracture-related healthcare services. Alendronate significantly reduced the proportion of patients utilizing fracture-related healthcare (emergency room, hospital, rehabilitation hospital or nursing home) by 25% (p = 0.038). Alendronate significantly reduced the costs associated with hip-fracture-related care by 58%, or $181 per patient randomized (p = 0.036). The reduction in fracture-related total costs was 35% ($190 per patient randomized) in the alendronate group relative to the placebo group (p = 0.114). Alendronate thus not only reduces the incidence of clinical fractures and associated morbidity, but reduces the proportion of patients utilizing the associated healthcare resources.
Details
- Title: Subtitle
- The effect of alendronate on fracture-related healthcare utilization and costs: the fracture intervention trial
- Creators
- E A Chrischilles - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City 52242, USAE J DasbachL M RubensteinJ R CookH K TaborD M Black - University of California San Francisco Medical CenterFracture Intervention Trial Research Group
- Resource Type
- Journal article
- Publication Details
- Osteoporosis international, Vol.12(8), pp.654-660
- Publisher
- England
- DOI
- 10.1007/s001980170065
- PMID
- 11580079
- ISSN
- 0937-941X
- eISSN
- 1433-2965
- Language
- English
- Date published
- 2001
- Academic Unit
- Pharmacy; Epidemiology; Internal Medicine
- Record Identifier
- 9983995154902771
Metrics
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