Journal article
The effect of aminophylline on pharmacological stress with intravenous adenosine
American journal of cardiac imaging, Vol.10(3), pp.149-153
1996
PMID: 8914700
Abstract
Myocardial perfusion imaging with adenosine pharmacological stress may be useful in patients with obstructive lung disease who are unable to exercise. However, these patients are often treated with medications containing theophylline, which is an adenosine antagonist. This study assessed the effect of aminophylline on coronary vasodilation produced by intravenous adenosine as commonly used during cardiac imaging. Changes in coronary flow velocity (measured by intracoronary Doppler catheter) heart rate, arterial pressure and changes in coronary resistance were measured during intravenous infusion of adenosine at 140 micrograms/kg/min before and after aminophylline, 6 mg/kg intravenously in 12 patients. After aminophylline infusion, the theophylline level averaged 14 +/- 1 microgram/mL. The coronary hemodynamic effects of adenosine were markedly attenuated by aminophylline. Adenosine increased coronary blood flow velocity by 192 +/- 39% at control and 78 +/- 16% after aminophylline (P < .05 v control). Adenosine produced a 63 +/- 5% decrease in coronary vascular resistance at control and 40 +/- 6% (P < .05) after aminophylline. The utility of myocardial imaging techniques using coronary vasodilation with intravenous adenosine may be reduced in patients treated with theophylline-containing preparations.
Details
- Title: Subtitle
- The effect of aminophylline on pharmacological stress with intravenous adenosine
- Creators
- P. J NAHSER - Cardiovascular Division and the Cardiovascular Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, United StatesR. E BROWN - Cardiovascular Division and the Cardiovascular Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, United StatesH OSKARSSON - Cardiovascular Division and the Cardiovascular Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, United StatesM. D WINNIFORD - Cardiovascular Division and the Cardiovascular Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, United StatesJ. D ROSSEN - Cardiovascular Division and the Cardiovascular Center Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- American journal of cardiac imaging, Vol.10(3), pp.149-153
- Publisher
- Saunders; Philadelphia, PA
- PMID
- 8914700
- ISSN
- 0887-7971
- Language
- English
- Date published
- 1996
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020847502771
Metrics
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