Journal article
The effect of androgen deprivation on malignant and benign prostate tissue
Medical oncology (Northwood, London, England), Vol.14(3-4), pp.145-152
09/01/1997
DOI: 10.1007/BF02989642
PMID: 9468037
Abstract
The purpose of this research was to describe the changes in marker expression and histologie morphology following androgen deprivation in malignant and benign human prostates. Fourteen patients receiving pre-radical prostatectomy total androgen deprivation had pre- and postandrogen deprivation evaluation of marker expression and histologie morphology (both malignant and benign). Marker expression was significantly reduced for serum (p < 0.0001) and tissue (p < 0.004) PSA as well as bcl-2 expression (p < 0.008). There were significant histologie increases in vacuolization (p < 0.001), pyknosis (p < 0.04), fibrosis (p < 0.01) and lymphocytic infiltration (p < 0.008) in the malignant tissue. There were significant increases in squamous metaplasia (p < 0.0002), fibrosis (p < 0.0005), basal cell hypertrophy (p < 0.0005) and lymphocytic infiltration (p < 0.0002) in the benign tissue. Androgen deprivation therapy produces significant changes in marker expression and morphology in prostate specimens. At times these iatrogenic changes can be confusing. Clinicians and pathologists must be aware of these changes.[PUBLICATION ABSTRACT]
Details
- Title: Subtitle
- The effect of androgen deprivation on malignant and benign prostate tissue
- Creators
- Patrick Guinan - University of Illinois at ChicagoDavid Didomenico - University of Illinois at ChicagoJames Brown - University of Illinois at ChicagoMichael Shaw - University of Illinois at ChicagoRoohollah Sharifi - University of Illinois at ChicagoVeronica Ray - University of Illinois at ChicagoSusan Shott - University of Illinois at ChicagoMarvin Rubenstein - University of Illinois at Chicago
- Resource Type
- Journal article
- Publication Details
- Medical oncology (Northwood, London, England), Vol.14(3-4), pp.145-152
- Publisher
- Springer Nature B.V
- DOI
- 10.1007/BF02989642
- PMID
- 9468037
- ISSN
- 1357-0560
- eISSN
- 1559-131X
- Language
- English
- Date published
- 09/01/1997
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Urology
- Record Identifier
- 9984320074502771
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