Journal article
The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: Assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography
Biological psychiatry (1969), Vol.41(5), pp.550-559
1997
DOI: 10.1016/S0006-3223(96)00110-2
PMID: 9046987
Abstract
Functional neuroimaging studies in schizophrenia have often been confounded by various factors including medication status. To explore the effects of antipsychotic medications on relative regional cerebral perfusion, we scanned a group of 33 persons with schizophrenia twice, while receiving a stable dose of antipsychotic and after being off antipsychotics for 3 weeks, using technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO-SPECT). We found that antipsychotics significantly increased the mean relative cerebral perfusion in the left basal ganglia. Additionally, patients receiving thiothixene (
n = 9) had a significantly greater increase in relative cerebral perfusion in the basal ganglia than patients receiving haloperidol (
n = 12). These findings indicate that antipsychotics lead to regional increases in cerebral perfusion and that antipsychotic status must be controlled for in functional neuroimaging studies. Functional neuroimaging techniques such as SPECT may be useful in furthering our understanding of the mechanism of antipsychotics.
Details
- Title: Subtitle
- The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: Assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography
- Creators
- Del D Miller - Mental Health Clinical Research Center, Iowa City, Iowa, USAKarim Rezai - Department of Radiology, University of Iowa Hospital and Clinics, University of Iowa College of Medicine, Iowa City, Iowa, USARandall Alliger - Department of Psychiatry, University of Iowa Hospital and Clinics, University of Iowa College of Medicine, Iowa City, Iowa, USANancy C Andreasen - Mental Health Clinical Research Center, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.41(5), pp.550-559
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0006-3223(96)00110-2
- PMID
- 9046987
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 1997
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984004098702771
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