Journal article
The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans
Interventional neuroradiology
05/13/2025
DOI: 10.1177/15910199251341035
PMCID: PMC12120354
PMID: 40356451
Abstract
ObjectiveAneurysm wall enhancement (AWE) is a potential biomarker of inflammation within the aneurysm wall that has been correlated with a higher risk of rupture. Aspirin (ASA) may decrease AWE due to its anti-inflammatory properties. We aimed to assess the effect of ASA on AWE in an animal model and a cohort of patients with unruptured intracranial aneurysms (UIAs).MethodsThree rabbits with elastase-induced aneurysms were exposed to ASA for 8 weeks and three rabbits were used as controls. 3 T high-resolution magnetic resonance imaging (HR-MRI) was performed at 7 days and 8 weeks to evaluate changes in AWE through histological and immunohistological analyses. Additionally, we evaluated AWE in patients who underwent imaging with a 3 T HR-MRI protocol. ASA exposure was defined as daily intake of 81 mg for at least six months prior to HR-MRI. AWE was quantified using three-dimensional AWE maps and histograms.ResultsAmong rabbits exposed to ASA, the mean AWE was lower at 8 weeks compared to the controls (2.11 vs 2.15,
= 0.13). Immunostaining of the aneurysm wall in rabbits that received ASA revealed a reduced expression of CD68 + or cyclooxygenase-2 + cells, compared to the controls. A total of 99 patients with 120 UIAs were included in the HR-MRI analysis of UIAs. UIAs exposed to ASA (22/120) had significantly lower median AWE than those that were not exposed (0.60 vs 0.72,
= 0.032).ConclusionASA therapy is associated with an objective reduction in AWE, suggesting a potential role in lowering the risk of aneurysm rupture.
Details
- Title: Subtitle
- The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans
- Creators
- Elena Sagues - University of IowaDiego Ojeda - University of ConnecticutAndres Gudino - University of IowaCarlos Dier - University of IowaNavami Shenoy - University of IowaArshaq Saleem - Carver College of Medicine, Iowa City, IA, USARamanthan Kadiervel - Mayo ClinicSebastian Sanchez - University of New HavenMaria B Torres - Department of Neurology, University of Iowa, Iowa City, IA, USAVance T Lehman - Mayo ClinicDavid Hasan - Duke UniversityEdgar A Samaniego - Department of Neurosurgery, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Interventional neuroradiology
- DOI
- 10.1177/15910199251341035
- PMID
- 40356451
- PMCID
- PMC12120354
- NLM abbreviation
- Interv Neuroradiol
- ISSN
- 2385-2011
- eISSN
- 2385-2011
- Publisher
- SAGE PUBLICATIONS INC
- Grant note
- Brain Aneurysm Foundation
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Most of this study was supported by personal funds. Dr. Edgar A. Samaniego received an award from the Brain Aneurysm Foundation (Renee Joyce Chair), which partially funded the study. No other grants were received from public, commercial, or not-for-profit funding agencies.
- Language
- English
- Electronic publication date
- 05/13/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984823071202771
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