Journal article
The effect of continuous glucose monitoring in well-controlled type 1 diabetes
Diabetes care, Vol.32(8), pp.1378-1383
08/2009
DOI: 10.2337/dc09-0108
PMCID: PMC2713649
PMID: 19429875
Abstract
OBJECTIVE The potential benefits of continuous glucose monitoring (CGM) in the management of adults and children with well-controlled type 1 diabetes have not been examined. RESEARCH DESIGN AND METHODS A total of 129 adults and children with intensively treated type 1 diabetes (age range 8-69 years) and A1C <7.0% were randomly assigned to either continuous or standard glucose monitoring for 26 weeks. The main study outcomes were time with glucose level < or =70 mg/dl, A1C level, and severe hypoglycemic events. RESULTS At 26 weeks, biochemical hypoglycemia (< or =70 mg/dl) was less frequent in the CGM group than in the control group (median 54 vs. 91 min/day), but the difference was not statistically significant (P = 0.16). Median time with a glucose level < or =60 mg/dl was 18 versus 35 min/day, respectively (P = 0.05). Time out of range (< or =70 or >180 mg/dl) was significantly lower in the CGM group than in the control group (377 vs. 491 min/day, P = 0.003). There was a significant treatment group difference favoring the CGM group in mean A1C at 26 weeks adjusted for baseline (P < 0.001). One or more severe hypoglycemic events occurred in 10 and 11% of the two groups, respectively (P = 1.0). Four outcome measures combining A1C and hypoglycemia data favored the CGM group in comparison with the control group (P < 0.001, 0.007, 0.005, and 0.003). CONCLUSIONS Most outcomes, including those combining A1C and hypoglycemia, favored the CGM group. The weight of evidence suggests that CGM is beneficial for individuals with type 1 diabetes who have already achieved excellent control with A1C <7.0%.
Details
- Title: Subtitle
- The effect of continuous glucose monitoring in well-controlled type 1 diabetes
- Creators
- Roy W BeckIrl B HirschLori LaffelWilliam V TamborlaneBruce W BodeBruce BuckinghamPeter ChaseRobert ClemonsRosanna Fiallo-ScharerLarry A FoxLisa K GilliamElbert S HuangCraig KollmanAaron J KowalskiJean M LawrenceJoyce LeeNelly MaurasMichael O'GradyKatrina J RuedyMichael TanseyEva TsalikianStuart A WeinzimerDarrell M WilsonHoward WolpertTim WysockiDongyuan XingJuvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.32(8), pp.1378-1383
- DOI
- 10.2337/dc09-0108
- PMID
- 19429875
- PMCID
- PMC2713649
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Language
- English
- Date published
- 08/2009
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093370902771
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