Journal article
The effect of diabetes on leucine and fucose incorporation into PNS myelin proteins
Hormone and metabolic research, Vol.13(6), pp.331-335
06/1981
DOI: 10.1055/s-2007-1019259
PMID: 7262834
Abstract
Peripheral neuropathy is a common complication associated with diabetes mellitus. Segmental demyelination and other pathological changes frequently accompany loss of sensory amd motor nerve function. Morphological changes seen in diabetic nerve myelin may be a result of altered Schwann cell metabolism under hyperglycemic conditions. Using both alloxan and streptozotocin - induced diabetic rats of 2, 4 and 8 months duration of diabetes, metabolic changes in isolated sciatic nerve myelin were assessed using a double-label in vitro incubation system. Incorporation of 3H-fucose and 1-14C-leucine into myelin was determined per microgram protein. Specific activities of incorporated protein precursors were compared as a ratio of fucose to leucine. Using the Newman-Kuels test for multiple comparisons, statistically significant increases were found in the incorporation ratios of diabetic rats at 2 and 4 months of diabetes when tested against age-matched controls.
Details
- Title: Subtitle
- The effect of diabetes on leucine and fucose incorporation into PNS myelin proteins
- Creators
- S BaughmanS Y FeltenW LeeS A MooreB L O'ConnorR G Peterson
- Resource Type
- Journal article
- Publication Details
- Hormone and metabolic research, Vol.13(6), pp.331-335
- Publisher
- Germany
- DOI
- 10.1055/s-2007-1019259
- PMID
- 7262834
- ISSN
- 0018-5043
- eISSN
- 1439-4286
- Grant note
- P60 AM 20542-03 / NIADDK NIH HHS
- Language
- English
- Date published
- 06/1981
- Academic Unit
- Pathology
- Record Identifier
- 9984047696902771
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