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The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma
Journal article   Open access   Peer reviewed

The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma

Kelly J Sigle, Gabriel Camaño-Garcia, Alicia L Carriquiry, Daniel M Betts, Markus H Kuehn and Gillian J McLellan
Veterinary ophthalmology, Vol.14 Suppl 1(SUPPL. 1), pp.48-53
09/2011
DOI: 10.1111/j.1463-5224.2011.00913.x
PMCID: PMC3348180
PMID: 21923823
url
https://doi.org/10.1111/j.1463-5224.2011.00913.xView
Published (Version of record) Open Access

Abstract

To determine the extent of fluctuation in circadian intraocular pressure (IOP) and the efficacy of topical dorzolamide 2% q 8 h in lowering IOP and blunting circadian fluctuation in IOP in glaucomatous cats. Seven adult cats with primary congenital glaucoma (PCG). Measurements of IOP and pupil diameter were obtained for both eyes (OU) of each cat q 4 h for 12 days. Cats were housed in a laboratory animal facility with a 12-h light:dark cycle. Baseline values were established for 2 days. For the next 5 days, placebo (1.4% polyvinyl alcohol) was administered OU q 8 h. Dorzolamide 2% was then administered OU q 8 h for a further 5 days. A multivariate mixed linear model was fitted to the data, with parameters estimated from a Bayesian perspective. The 4 am time point was selected as the reference for the purposes of comparisons. Estimated mean IOP for the reference time point pre-treatment was symmetric (about 33 mmHg OU). In all cats, IOP was significantly lower during the diurnal phase, relative to the 4 am measurements, with highest IOP observed 2-6 h after the onset of the dark phase. Circadian fluctuations in IOP were dampened during the treatment period. There was a significant decrease in IOP in all cats during the dorzolamide treatment period (estimated mean for the treatment period reference = 17.9 mmHg OU). Topical dorzolamide 2% q 8 h is effective in reducing IOP and IOP fluctuation in cats with PCG.
 Thiophenes - therapeutic use Cats Intraocular Pressure - drug effects Carbonic Anhydrase Inhibitors - administration & dosage Intraocular Pressure - physiology Cat Diseases - drug therapy Glaucoma - drug therapy Male Cat Diseases - congenital Circadian Rhythm - physiology Thiophenes - administration & dosage Glaucoma - veterinary Glaucoma - congenital Administration, Ophthalmic - veterinary Animals Sulfonamides - therapeutic use Cat Diseases - physiopathology Female Glaucoma - physiopathology Sulfonamides - administration & dosage Carbonic Anhydrase Inhibitors - therapeutic use

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