Journal article
The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men
The Journal of urology, Vol.156(2), pp.438-442
08/1996
DOI: 10.1016/S0022-5347(01)65871-3
PMID: 8683697
Abstract
Purpose: We evaluated the effect of exogenous testosterone administration on serum total and free prostate specific antigen (PSA) in healthy young men. Materials and Methods: Nine volunteers received either 100, 250 or 500 mg. testosterone by intramuscular injection each week for 15 weeks. Blood was drawn every other week for 28 weeks and at week 40. Serum total and free PSA, and total and free testosterone were measured and compared to baseline values. Results: Significant elevations in total and free testosterone occurred but no significant change in serum total and free PSA was detected. Conclusions: Serum PSA is not responsive to elevated serum testosterone levels in healthy young men. PSA metabolism in the normal prostate is unclear but our findings may have implications for differentiation of pathological conditions of the human prostate.
Details
- Title: Subtitle
- The effect of exogenous testosterone on total and free prostate specific antigen levels in healthy young men
- Creators
- Christopher S. Cooper - University of IowaJohn H. MacIndoe - University of IowaPaul J. Perry - University of IowaWilliam R. Yates - University of IowaRichard D. Williams - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.156(2), pp.438-442
- DOI
- 10.1016/S0022-5347(01)65871-3
- PMID
- 8683697
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 08/1996
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Urology; Medicine Administration
- Record Identifier
- 9984319977302771
Metrics
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