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The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates
Journal article   Peer reviewed

The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates

Thomas N George, Karen J Johnson, James N Bates and Jeffrey L Segar
The Journal of pediatrics, Vol.132(4), pp.731-734
1998
DOI: 10.1016/S0022-3476(98)70370-1
PMID: 9580780

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Abstract

The effect of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation was studied in nine newborn infants with resolving pulmonary hypertension. Infants treated with iNO at 40 ppm for 30 minutes had bleeding times that were nearly twofold longer than those obtained 24 hours after iNO was discontinued. iNO had no effect on in vitro platelet aggregation studies. (J Pediatr 1998;132:731-4.)
NO PPHN iNO

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