Journal article
The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Diabetes (New York, N.Y.), Vol.55(12), pp.3556-3565
12/2006
DOI: 10.2337/db06-0653
PMCID: PMC2701297
PMID: 17130504
Abstract
The Epidemiology of Diabetes Interventions and Complications (EDIC) study, an observational follow-up of the Diabetes Control and Complications Trial (DCCT) type 1 diabetes cohort, measured coronary artery calcification (CAC), an index of atherosclerosis, with computed tomography (CT) in 1,205 EDIC patients at approximately 7-9 years after the end of the DCCT. We examined the influence of the 6.5 years of prior conventional versus intensive diabetes treatment during the DCCT, as well as the effects of cardiovascular disease risk factors, on CAC. The prevalences of CAC >0 and >200 Agatston units were 31.0 and 8.5%, respectively. Compared with the conventional treatment group, the intensive group had significantly lower geometric mean CAC scores and a lower prevalence of CAC >0 in the primary retinopathy prevention cohort, but not in the secondary intervention cohort, and a lower prevalence of CAC >200 in the combined cohorts. Waist-to-hip ratio, smoking, hypertension, and hypercholesterolemia, before or at the time of CT, were significantly associated with CAC in univariate and multivariate analyses. CAC was associated with mean HbA(1c) (A1C) levels before enrollment, during the DCCT, and during the EDIC study. Prior intensive diabetes treatment during the DCCT was associated with less atherosclerosis, largely because of reduced levels of A1C during the DCCT.
Details
- Title: Subtitle
- The effect of intensive glycemic treatment on coronary artery calcification in type 1 diabetic participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
- Creators
- Patricia A Cleary - Diabetes Unit, Massachusetts General Hospital, 32 Fruit St., Boston, MA 02114-2698, USATrevor J OrchardSaul GenuthNathan D WongRobert DetranoJye-Yu C BacklundBernard ZinmanAlan JacobsonWanjie SunJohn M LachinDavid M NathanDiabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
- Contributors
- W Sivitz (Contributor) - University of Iowa, Endocrinology and Metabolism
- Resource Type
- Journal article
- Publication Details
- Diabetes (New York, N.Y.), Vol.55(12), pp.3556-3565
- Publisher
- United States
- DOI
- 10.2337/db06-0653
- PMID
- 17130504
- PMCID
- PMC2701297
- ISSN
- 0012-1797
- eISSN
- 1939-327X
- Grant note
- N01 DK062204-007 / NIDDK NIH HHS
- Language
- English
- Date published
- 12/2006
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979934902771
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