Journal article
The effect of mechanical ventilation on oxygen consumption in critically ill patients
American journal of respiratory and critical care medicine, Vol.151(1), pp.210-214
1995
DOI: 10.1164/ajrccm.151.1.7812556
PMID: 7812556
Abstract
We measured oxygen consumption (VO2) during spontaneous breathing with continuous positive airway pressure (CPAP), assist control ventilation (AC), and control ventilation during muscle relaxation (AC-MR) in eight patients undergoing resuscitation from cardiopulmonary failure. VO2 decreased in all eight patients between CPAP and AC-MR; mean VO2 (255 +/- 92 ml/min) on CPAP exceeded that on AC-MR (209 +/- 79 ml/min) (p < 0.005). Compared with CPAP, AC without MR reduced VO2 in five of eight patients and mean VO2 (227 +/- 59 ml/min) tended to decrease (p = 0.14); clinical examination did not distinguish patients requiring MR to reduce VO2 further. If VO2 on CPAP approximates VO2 during spontaneous breathing, the difference between CPAP and AC-MR (VO2resp) represents the decrement of VO2 that can be obtained during muscle rest. Both VO2resp and the mechanical work performed by the ventilator on the respiratory system were increased to about five times the efficiencies reported for normal patients, but VO2resp did not correlate with the mechanical work because of a wide range of respiratory muscle efficiencies. These efficiencies are less than those reported in normal patients, which may reflect the effect of sepsis, acidemia, hypoxia, or other conditions in these patients. We conclude that mechanical ventilation with muscle relaxation reduces VO2 by more than 20%; beyond stabilizing pulmonary gas exchange, these interventions preserve limited O2 delivery (QO2) for other vital organs.
Details
- Title: Subtitle
- The effect of mechanical ventilation on oxygen consumption in critically ill patients
- Creators
- C. A MANTHOUS - Univ. Chicago, dep. medicine, Chicago IL, United StatesJ. B HALL - Univ. Chicago, dep. medicine, Chicago IL, United StatesR KUSHNER - Univ. Chicago, dep. medicine, Chicago IL, United StatesG. A SCHMIDT - Univ. Chicago, dep. medicine, Chicago IL, United StatesG RUSSO - Univ. Chicago, dep. medicine, Chicago IL, United StatesL. D. H WOOD - Univ. Chicago, dep. medicine, Chicago IL, United States
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.151(1), pp.210-214
- Publisher
- American Lung Association
- DOI
- 10.1164/ajrccm.151.1.7812556
- PMID
- 7812556
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Language
- English
- Date published
- 1995
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094595702771
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