Journal article
The effect of oxygen concentration on atelectasis formation during induction of general anesthesia in children: A prospective randomized controlled trial
Pediatric anesthesia, Vol.31(12), pp.1276-1281
12/2021
DOI: 10.1111/pan.14304
PMID: 34614266
Abstract
Background
In adults, the use of lower oxygen concentration during induction is associated with less atelectasis formation without an increase in incidence of hypoxia. However, it is unknown whether this remains true in the pediatric patients.
Methods
Fifty-four pediatric patients who were scheduled to undergo elective lower abdominal surgery were randomized to one of three oxygenation groups: 100%, 80%, or 60% oxygen (in air). During anesthesia induction, patients were ventilated with sevoflurane in 100%, 80%, or 60% oxygen. Endotracheal intubation and mechanical ventilation were performed. Atelectasis was diagnosed using LUS, which was performed after anesthetic induction and at the end of surgery.
Results
We assessed atelectasis after anesthetic induction and at the end of surgery. After anesthetic induction, the number of atelectatic lung regions was significantly different among the three groups (median [IQR], 2.0 [1.0–2.5], 2.0 [1.0–2.8], and 3.0 [2.0–3.0] in the 60%, 80%, and 100% oxygen groups, p = .033) and between the 60% and 100% groups (p = .015), but not between 80% and 100% groups (p = .074). However, no differences in the number of atelectatic lung regions were found among the three groups at the end of surgery (2.0 [1.3–3.8], 3.0 [1.8–3.0], and 4.0 [2.0–4.0] in the 60%, 80%, and 100% oxygen groups; p = .169).
Conclusion
Lower oxygen concentration during anesthetic induction is associated with less atelectasis formation immediately after anesthetic induction in children. In addition, applying 80% oxygen instead of 100% oxygen is not enough to prevent atelectasis formation, and 60% oxygen should be applied to prevent atelectasis. However, this effect does not last until the end of surgery.
Details
- Title: Subtitle
- The effect of oxygen concentration on atelectasis formation during induction of general anesthesia in children: A prospective randomized controlled trial
- Creators
- Hyun Il Kim - Yonsei UniversityJi Young Min - Catholic University of KoreaJeong-Rim Lee - Yonsei UniversityChoi Kwan Woong - National Health Insurance ServiceMatthew R. Cho - National Health Insurance ServiceHyo‐Jin Byon - Yonsei University
- Resource Type
- Journal article
- Publication Details
- Pediatric anesthesia, Vol.31(12), pp.1276-1281
- DOI
- 10.1111/pan.14304
- PMID
- 34614266
- NLM abbreviation
- Paediatr Anaesth
- ISSN
- 1155-5645
- eISSN
- 1460-9592
- Number of pages
- 6
- Language
- English
- Date published
- 12/2021
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806513502771
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