The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study

Eran Chemerinski; Robert G Robinson; Stephan Arndt; James T Kosier

doi:10.1097/00005053-200107000-00002

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The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study

Journal article

Peer reviewed

The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study

Eran Chemerinski, Robert G Robinson, Stephan Arndt and James T Kosier

The journal of nervous and mental disease, Vol.189(7), pp.421-425

07/2001

DOI: 10.1097/00005053-200107000-00002

PMID: 11504318

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Abstract

Poststroke depression has been associated with impaired recovery of activities of daily living (ADL) during the first 2 years after stroke. This study examined the effect of remission of poststroke depression on recovery in ADL in a double-blind randomized treatment study. Based on a semistructured psychiatric exam and DSM-IV diagnostic criteria, a consecutive series of 23 patients who met criteria for major depression (N = 16) or minor depression (N = 7) were selected and randomly assigned to either active treatment (nortriptyline) or placebo. Functional physical (i.e., ADL) impairment was assessed using the Johns Hopkins Functioning Inventory (JHFI). Patients whose depressive disorder remitted at follow-up had significantly greater recovery in ADL functions compared with patients whose depression did not remit. There were no differences in demographic variables, lesion characteristics, and neurological symptoms between the two groups, which would explain the significantly greater improvement among the remitted patients. Because both major and minor depression patients who remitted showed greater improvement in ADL than nonremitted patients some of whom were treated with active and some with placebo medication, nonpharmacotherapeutic mechanisms related to recovery from depression appear to mediate this enhanced recovery.

Neuropharmacology

Psychopharmacology

Biological and medical sciences

Medical sciences

Pharmacology. Drug treatments

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Psychology. Psychoanalysis. Psychiatry

Details

Title: Subtitle: The effect of remission of poststroke depression on activities of daily living in a double-blind randomized treatment study
Creators: Eran Chemerinski - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242, United States
Robert G Robinson - University of Iowa
Stephan Arndt - University of Iowa
James T Kosier - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: The journal of nervous and mental disease, Vol.189(7), pp.421-425
DOI: 10.1097/00005053-200107000-00002
PMID: 11504318
NLM abbreviation: J Nerv Ment Dis
ISSN: 0022-3018
eISSN: 1539-736X
Publisher: Lippincott Williams & Wilkins
Number of pages: 5
Language: English
Date published: 07/2001
Academic Unit: Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
Record Identifier: 9985132189402771

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