Journal article
The effect of salts in aqueous media on the formation of the BSA corona on SiO 2 nanoparticles
Colloids and surfaces, B, Biointerfaces, Vol.179, pp.374-381
07/01/2019
DOI: 10.1016/j.colsurfb.2019.04.012
PMID: 30999116
Abstract
Protein-nanoparticle interactions are garnering attention due to their potential impacts on human health and environmental contamination. The colloidal properties of nanoparticles (NPs) in aqueous media may differ in the presence of natural materials such as salts and proteins. In this study, the interactions between bovine serum albumin (BSA) and fumed hydrophilic silicon dioxide (SiO
) NPs were studied in aqueous solutions under variable pH or ion composition. Investigation of hydrodynamic diameter and zeta potential changes to nanoparticles upon addition of BSA, the adsorption of BSA to the SiO
NP surface, and the interaction energy between particles revealed that buffered solutions promote protein adsorption onto NPs and particle agglomeration. The effects of ionic salt solutions were dependent on the ion charge, with negatively charged ions stabilizing the system and positively charged ions promoting protein-nanoparticle interactions. These data highlight that physiologically relevant salts affect protein corona formation on non-toxic, amorphous SiO
NPs and spur the need for well-defined characterization conditions when determining potential toxicity of NPs upon human or animal exposure.
Details
- Title: Subtitle
- The effect of salts in aqueous media on the formation of the BSA corona on SiO 2 nanoparticles
- Creators
- Brittany E Givens - University of IowaElizabeth Wilson - University of IowaJennifer Fiegel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Colloids and surfaces, B, Biointerfaces, Vol.179, pp.374-381
- DOI
- 10.1016/j.colsurfb.2019.04.012
- PMID
- 30999116
- ISSN
- 0927-7765
- eISSN
- 1873-4367
- Grant note
- DOI: 10.13039/100000001, name: National Science Foundation, award: CHE-1062575; name: University of Iowa Center for Exemplary Mentoring; name: University of Iowa Graduate College Dean’s Research Fellowship program
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Pharmacy Practice and Science; Chemical and Biochemical Engineering
- Record Identifier
- 9984197249602771
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