Journal article
The effect of weight-based chemotherapy dosing in a cohort of gynecologic oncology patients
Gynecologic Oncology, Vol.138(1), pp.154-158
07/2015
DOI: 10.1016/j.ygyno.2015.04.040
PMID: 25958318
Abstract
Many clinicians limit chemotherapy doses based on a maximum body surface area (BSA) of 2m2. We sought to determine how chemotherapy-related toxicities compared between groups of patients that varied with respect to BSA. We hypothesized that obese patients receiving weight-based (WB) dosing would not have significantly higher chemotherapy-related toxicities than control groups. We performed a retrospective review of patients with BSA≥2m2 who received WB chemotherapy for a gynecologic cancer between January and August 2013. Subjects were matched with two controls: patients with BSA<2m2 who received WB dosing, and patients with BSA≥2m2 who received capped dosing at BSA=2m2. Groups were matched for medical co-morbidities and prior cancer treatment. Demographic and clinical information was extracted and analyzed via ANOVA and Fisher's exact test. A total of 75 patients were included. The three groups were similar in their medical co-morbidities and prior cancer treatment. When comparing pre- and post-treatment laboratory values, there was no difference in hematologic toxicities. There was no difference between groups with regard to treatment delays, unplanned admissions, transfusions, or dose reductions for toxicity. Gynecologic cancer patients with BSA≥2m2 treated with WB chemotherapy had no increase in hematologic or non-hematologic toxicities when compared to controls. Consideration should be given to using WB dosing in obese patients with gynecologic malignancies. Further investigation is required to determine the effect of WB dosing on progression-free and overall survival in obese gynecologic cancer patients. •No serous effects were noted in obese patients who received full weight- based dosing•Heme toxicities were not seen in obese patients with capped vs weight-based dosing•Weight-based dosing in gynecologic oncology patients appears to be well tolerated
Details
- Title: Subtitle
- The effect of weight-based chemotherapy dosing in a cohort of gynecologic oncology patients
- Creators
- Jean Hansen - Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAJean-Marie Stephan - Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMichele Freesmeier - Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USADavid Bender - Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAAnna Button - Department of Biostatistics, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USAMichael J Goodheart - Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Gynecologic Oncology, Vol.138(1), pp.154-158
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.ygyno.2015.04.040
- PMID
- 25958318
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Grant note
- name: The Dorene Knapp Ovarian Cancer Fund; name: CCKMA Ovarian Cancer Fund
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983930978302771
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