Journal article
The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research
Antimicrobial stewardship & healthcare epidemiology : ASHE, Vol.3(1), e168
10/01/2023
DOI: 10.1017/ash.2023.447
PMCID: PMC10644173
PMID: 38028898
Appears in UI Libraries Support Open Access
Abstract
Objective: We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals. Design: Systematic literature review/meta-analysis. Methods: We searched PubMed, Cumulative Index to Nursing and Allied Health, EMBASE, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from December 1, 2019, to June 2, 2023, for studies evaluating the COVID-19 vaccine effectiveness (VE) against post-COVID conditions among fully vaccinated individuals who received two doses of COVID-19 vaccine. A post-COVID condition was defined as any symptom that was present four or more weeks after COVID-19 infection. We calculated the pooled diagnostic odds ratio (DOR) (95% confidence interval) for post-COVID conditions between fully vaccinated and unvaccinated individuals. Vaccine effectiveness was estimated as 100% x (1-DOR). Results: Thirty-two studies with 775,931 individuals evaluated the effect of vaccination on post-COVID conditions, of which, twenty-four studies were included in the meta-analysis. The pooled DOR for post-COVID conditions among fully vaccinated individuals was 0.680 (95% CI: 0.523–0.885) with an estimated VE of 32.0% (11.5%–47.7%). Vaccine effectiveness was 36.9% (23.1%–48.2%) among those who received two doses of COVID-19 vaccine before COVID-19 infection and 68.7% (64.7%–72.2%) among those who received three doses before COVID-19 infection. The stratified analysis demonstrated no protection against post-COVID conditions among those who received COVID-19 vaccination after COVID-19 infection. Conclusions: Receiving a complete COVID-19 vaccination prior to contracting the virus resulted in a significant reduction in post-COVID conditions throughout the study period, including during the Omicron era. Vaccine effectiveness demonstrated an increase when supplementary doses were administered.
Details
- Title: Subtitle
- The effectiveness of COVID-19 vaccine in the prevention of post-COVID conditions: a systematic literature review and meta-analysis of the latest research
- Creators
- Alexandre Marra - University of IowaTakaaki Kobayashi - University of IowaGustavo Yano Callado - Hospital Israelita Albert EinsteinIsabele PardoMaria Gutfreund - Hospital Israelita Albert EinsteinMariana Kim Hsieh - Hospital Israelita Albert EinsteinVivian Lin - Hospital Israelita Albert EinsteinMohammed Alsuhaibani - King Faisal Specialist Hospital & Research CentreShinya Hasegawa - University of IowaJoseph Tholany - University of IowaEli Perencevich - Iowa City VA Health Care SystemJorge Salinas - Stanford UniversityMichael Edmond - West Virginia UniversityLuiz Vicente Rizzo - Hospital Israelita Albert Einstein
- Resource Type
- Journal article
- Publication Details
- Antimicrobial stewardship & healthcare epidemiology : ASHE, Vol.3(1), e168
- DOI
- 10.1017/ash.2023.447
- PMID
- 38028898
- PMCID
- PMC10644173
- NLM abbreviation
- Antimicrob Steward Healthc Epidemiol
- eISSN
- 2732-494X
- Publisher
- Cambridge University Press
- Language
- English
- Date published
- 10/01/2023
- Academic Unit
- Infectious Diseases; Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984475075902771
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