Journal article
The effectiveness of pulmonary hypertension screening in infants born preterm
Early human development, Vol.209, 106342
10/2025
DOI: 10.1016/j.earlhumdev.2025.106342
PMCID: PMC12377894
PMID: 40680400
Abstract
Objective: To determine if pulmonary hypertension (PH) screening in at-risk infants born preterm reduces morbidity and/or NICU length of stay.
Study design: This single-center retrospective cohort chart review compared infants born <32 weeks gestational age (GA) before and after the implementation of an updated PH screening guideline. Screening eligibility and PH diagnosis were determined by applying the standardized criteria to patients in both epochs. NICU and post-discharge outcomes were determined by chart review.
Results: Pre- (N = 513) and post-screening (N = 544) epochs had similar gestational age and demographic characteristics. More echocardiograms were obtained in post-screening infants resulting in more PH diagnoses (11.5 % vs. 16.5 %, p = 0.02) at a younger median post-natal age [day of life 73 (28-193) vs. 55 (28-212), median and range, p = 0.01]. PH+ infants in the post-screen epoch were discharged at a younger median post-natal age [127 (49-407) vs 113.5 (46-433) days, p = 0.02] and corrected GA [43.6 (36.7-87.4) vs 41.7 (36.6-64.9) weeks, p = 0.03].
Conclusion: PH screening protocol with multidisciplinary team involvement may be associated with increased detection of PH in at risk infants yet a shorter NICU stay in infants with PH.
Details
- Title: Subtitle
- The effectiveness of pulmonary hypertension screening in infants born preterm
- Creators
- Stephanie VachonRajiv DevanagondiAndrew DylagHongyue WangGloria Pryhuber
- Resource Type
- Journal article
- Publication Details
- Early human development, Vol.209, 106342
- DOI
- 10.1016/j.earlhumdev.2025.106342
- PMID
- 40680400
- PMCID
- PMC12377894
- NLM abbreviation
- Early Hum Dev
- ISSN
- 0378-3782
- eISSN
- 1872-6232
- Publisher
- Elsevier
- Grant note
- Advancing Translational Sciences of the National Institutes of Health through the University of Rochester CTSA: UL1 TR002001 University of Rochester Medi-cal Center Schor AwardURMC Schor Award Selection Committee . URMC Pulmonary Hypertension TeamURMC, Cardiology Informatics, Information of Systems Division
This work was supported by the Advancing Translational Sciences of the National Institutes of Health through the University of Rochester CTSA [UL1 TR002001] ; University of Rochester Medical Center Schor Award [2023] center dot URMC Schor Award Selection Committee center dot URMC Pulmonary Hypertension Team and the Bronchopulmonary Dysplasia Workgroup center dot Jamey Tulluch, URMC, Data Analysis Manager, Division of Neonatology center dot Laura Hatz, URMC, Cardiology Informatics, Information of Systems Division
- Language
- English
- Electronic publication date
- 07/15/2025
- Date published
- 10/2025
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984848020102771
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