The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: Results of a matched follow-up study

Dale W Stovall; Bradley J. Van Voorhis; Kerry L Mattingly; Amy E.T. Sparks; Frederick K Chapler; Craig H. Syrop

doi:10.1016/S0015-0282(16)58274-0

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The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: Results of a matched follow-up study

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The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: Results of a matched follow-up study

Dale W Stovall, Bradley J. Van Voorhis, Kerry L Mattingly, Amy E.T. Sparks, Frederick K Chapler and Craig H. Syrop

Fertility and sterility, Vol.65(5), pp.986-991

05/01/1996

DOI: 10.1016/S0015-0282(16)58274-0

PMID: 08612862

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Abstract

Objective: To compare cryopreserved ET pregnancy rates in subjects receiving either sublingual parenteral P. Design: Matched follow-up study. Setting: University-based assisted reproduction program. Patients: Women undergoing cryopreserved ET between January 1993, and December 1994. Cases received a hormone replacement protocol containing oral E2 and sublingual P and controls received a hormone replacement protocol containing oral E2 and parenteral P. Cases and controls were matched one-to-one according to age, number of embryos transferred, embryo grade, and route of ET. Interventions: Cryopreserved embryos were thawed and transferred in all patients in an identical manner independent of the route of P administration. Main outcome measures: Clinical and ongoing pregnancy rates. Results: Of 61 ET cycles performed in the sublingual P group, there were 16 clinical pregnancies (26.2%) and 12 ongoing pregnancies (19.7%). Of the 61 ET cycles in the parenteral P group, there were 14 clinical pregnancies (23.0%) and 11 ongoing pregnancies (18.0%). A chi 2 test revealed no significant differences in either clinical or ongoing pregnancy rates according to the route of P administration. Conclusions: This data suggests that sublingual P administration is an effective alternative to parenteral P administration in preparing the endometrium for the implantation of cryopreserved embryos.

Obstetrics and Gynecology

Details

Title: Subtitle: The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: Results of a matched follow-up study
Creators: Dale W Stovall
Bradley J. Van Voorhis - University of Iowa
Kerry L Mattingly
Amy E.T. Sparks - University of Iowa
Frederick K Chapler
Craig H. Syrop - University of Iowa
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.65(5), pp.986-991
DOI: 10.1016/S0015-0282(16)58274-0
PMID: 08612862
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
Language: English
Date published: 05/01/1996
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557403402771

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