Journal article
The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation
Blood, Vol.46(3), pp.309-320
09/1975
DOI: 10.1182/blood.V46.3.309.309
PMID: 167888
Abstract
The influence of freshly purified ATP on the effects of aggregating agents on human platelets was studied. ATP inhibited aggregation induced by ADP competitively (Ki = 20 muM) and immediately without need for prior incubation. ATP had no effect on primary aggregation induced by adrenaline, thrombin, vasopressin, or 5-hydroxytryptamine (5HT). ATP inhibited the shape change and the consumption of metabolic ATP induced by ADP but did not inhibit these effects when induced by thrombin, vasopressin, or 5HT. ATP counteracted the inhibition by ADP of PGE1-stimulated cyclic AMP production in platelets but did not reduce inhibition by adrenaline. It is concluded that adrenaline, thrombin, 5HT, and vasopressin each can induce primary aggregation of human platelets by a mechanism independent of extracellular ADP.
Details
- Title: Subtitle
- The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation
- Creators
- D E MacfarlaneD C Mills
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.46(3), pp.309-320
- DOI
- 10.1182/blood.V46.3.309.309
- PMID
- 167888
- NLM abbreviation
- Blood
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Language
- English
- Date published
- 09/1975
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094736002771
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