The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process

Ann Jacob; Abhishek Parolia; Allan Pau; Fabian Davamani Amalraj

doi:10.1186/s12906-015-0814-1

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The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process

Journal article

Open access

The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process

Ann Jacob, Abhishek Parolia, Allan Pau and Fabian Davamani Amalraj

BMC complementary and alternative medicine, Vol.15(1), pp.294-294

08/25/2015

DOI: 10.1186/s12906-015-0814-1

PMCID: PMC4549008

PMID: 26303848

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https://doi.org/10.1186/s12906-015-0814-1View

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Abstract

To evaluate and compare the effects of ethanolic extracts of Malaysian propolis and Brazilian red propolis at different concentrations on the migration and proliferation of fibroblast cells. Malaysian and Brazilian red propolis crude samples were extracted using ethanol. Their wound healing effects were tested in vitro on the normal human fibroblast cell line CRL-7522. Cell migration and proliferation assays were carried out using propolis concentrations of 1, 10, 100, 250, 500 and 1000 μg/mL. The data were analyzed using one-way ANOVA and post hoc Bonferroni tests (α=0.05). Malaysian and Brazilian red propolis followed a concentration-dependent increasing and decreasing trend. Malaysian propolis showed the fastest migration rate at 250 μg/mL which was statistically significant (p<0.05) and maximum proliferation at 500 μg/mL with no significant difference (p>0.05) compared to control. Brazilian red propolis showed a slight increase in migration and proliferation at 10 and 100 μg/mL, respectively with no significant difference (p>0.05) compared to control, while concentrations above these conferred inhibitory effects. Malaysian and Brazilian red propolis show potential to assist in wound healing, depending on their concentration.

Brazil

Malaysia

Cell Line

Cell Movement - drug effects

Fibroblasts - drug effects

Humans

Propolis - pharmacology

Wound Healing - drug effects

Details

Title: Subtitle: The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process
Creators: Ann Jacob - IMU University
Abhishek Parolia - IMU University
Allan Pau - IMU University
Fabian Davamani Amalraj - University of Kuala Lumpur
Resource Type: Journal article
Publication Details: BMC complementary and alternative medicine, Vol.15(1), pp.294-294
DOI: 10.1186/s12906-015-0814-1
PMID: 26303848
PMCID: PMC4549008
NLM abbreviation: BMC Complement Altern Med
ISSN: 1472-6882
eISSN: 1472-6882
Language: English
Date published: 08/25/2015
Academic Unit: Endodontics
Record Identifier: 9984446415702771

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