Journal article
The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women
American journal of hypertension, Vol.26(4), pp.503-510
04/2013
DOI: 10.1093/ajh/hps074
PMCID: PMC3590008
PMID: 23467206
Abstract
BACKGROUND Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58±2 years. METHODS Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25mg/kg, followed by a continuous infusion at 0.004mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. RESULTS Acute beta-blockade increased the aortic augmentation index (AIx) in postmenopausal women (32±2% vs. 35±2%, P < 0.01). However, AIx adjusted for a heart rate of 75 bpm (AIx75) was unchanged (25±2% vs. 24±2%, P > 0.05). The changes in AIx, AIx75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05). Conclusions As compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.
Details
- Title: Subtitle
- The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women
- Creators
- Darren P Casey - Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. casey.darren@mayo.eduTimothy B CurryNisha CharkoudianMichael J JoynerEmma C Hart
- Resource Type
- Journal article
- Publication Details
- American journal of hypertension, Vol.26(4), pp.503-510
- Publisher
- United States
- DOI
- 10.1093/ajh/hps074
- PMID
- 23467206
- PMCID
- PMC3590008
- ISSN
- 0895-7061
- eISSN
- 1879-1905
- Grant note
- UL1 RR024150 / NCRR NIH HHS AR55819 / NIAMS NIH HHS DK082424 / NIDDK NIH HHS K23 DK082424 / NIDDK NIH HHS F32 AR055819 / NIAMS NIH HHS HL46493 / NHLBI NIH HHS R01 HL046493 / NHLBI NIH HHS HL083947 / NHLBI NIH HHS R01 HL083947 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984046917202771
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