Journal article
The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes
Diabetes care, Vol.29(1), pp.20-25
01/2006
DOI: 10.2337/diacare.29.01.06.dc05-1192
PMCID: PMC2396943
PMID: 16373890
Abstract
To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes.
Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods of walking on a treadmill to a target heart rate of 140 bpm and three 5-min rest periods. Blood glucose and plasma glucagon, cortisol, growth hormone, and norepinephrine concentrations were measured before, during, and after exercise.
In most subjects (83%), plasma glucose concentration dropped at least 25% from baseline, and 15 (30%) subjects became hypoglycemic (< or = 60 mg/dl) or were treated for low glucose either during or immediately following the exercise session. The incidence of hypoglycemia and/or treatment for low glucose varied significantly by baseline glucose, occurring in 86 vs. 13 vs. 6% of subjects with baseline values <120, 120-180, and >180 mg/dl, respectively (P < 0.001). Exercise-induced increases in growth hormone and norepinephrine concentrations were marginally higher in subjects whose glucose dropped < or = 70 mg/dl. Treatment of hypoglycemia with 15 g of oral glucose resulted in only about a 20-mg/dl rise in glucose concentrations.
In youth with type 1 diabetes, prolonged moderate aerobic exercise results in a consistent reduction in plasma glucose and the frequent occurrence of hypoglycemia when preexercise glucose concentrations are <120 mg/dl. Moreover, treatment with 15 g of oral glucose is often insufficient to reliably treat hypoglycemia during exercise in these youngsters.
Details
- Title: Subtitle
- The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes
- Creators
- Michael J Tansey - DirecNet Coordinating Center, Jaeb Center for Health Research, Tampa, FL 33647, USA. direcnet@jaeb.orgEva TsalikianRoy W BeckNelly MaurasBruce A BuckinghamStuart A WeinzimerKathleen F JanzCraig KollmanDongyuan XingKatrina J RuedyMichael W SteffesTimothy M BorlandRavinder J SinghWilliam V TamborlaneDiabetes Research in Children Network (DirecNet) Study Group
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.29(1), pp.20-25
- DOI
- 10.2337/diacare.29.01.06.dc05-1192
- PMID
- 16373890
- PMCID
- PMC2396943
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- RR00059 / NCRR NIH HHS U10 HD041906 / NICHD NIH HHS M01 RR000125 / NCRR NIH HHS M01 RR000069 / NCRR NIH HHS U10 HD041915 / NICHD NIH HHS HD041906 / NICHD NIH HHS M01 RR000585 / NCRR NIH HHS M01 RR00585 / NCRR NIH HHS U10 HD041890 / NICHD NIH HHS U10 HD041915-01 / NICHD NIH HHS HD041919 / NICHD NIH HHS U10 HD041919-01 / NICHD NIH HHS RR00070 / NCRR NIH HHS U10 HD041918-01 / NICHD NIH HHS RR00125 / NCRR NIH HHS M01 RR000070 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS HD041908 / NICHD NIH HHS HD041918 / NICHD NIH HHS U10 HD041906-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS U10 HD041908-01 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS U01 HD041890-01 / NICHD NIH HHS M01 RR000059 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS HD041915 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
- Language
- English
- Date published
- 01/2006
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology
- Record Identifier
- 9984093476102771
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