Journal article
The effects of beta-adrenoreceptor blockers on blood pressure responses to central angiotensin II
Neuropharmacology, Vol.20(8), pp.719-726
1981
DOI: 10.1016/0028-3908(81)90219-7
PMID: 6116206
Abstract
Experiments were carried out in rats to study the effects of beta-adrenoreceptor blockade on the central angiotensin blood pressure responses. Immediately following acute administration of sotalol,
l-propranolol and
d-propranolol into the brain ventricles (i.c.v.), the beta-adrenoreceptor antagonists and
d-propranolol produced transient increases of resting blood pressure, but they reduced the blood pressure increases following intraventricular injection of angiotensin II. Chronic oral beta-adrenoreceptor blockade with
dl-propranolol racemate reduced heart rate in Wistar Kyoto rats and in spontaneously hypertensive rats. Mean arterial blood pressure decreased in spontaneously hypertensive rats but not in Wistar Kyoto rats. The blood pressure increases following intraventricular angiotensin II infusions were greater in spontaneously hypertensive than in Wistar Kyoto rats. Chronic oral propranolol treatment reduced the angiotensin II-induced blood pressure increases in Wistar Kyoto but not in spontaneously hypertensive rats.
It is concluded that beta-adrenoreceptor blockers inhibit the blood pressure effects of brain angiotensin, but this appears not to be solely due to specific blockade of brain beta-adrenoreceptors.
Details
- Title: Subtitle
- The effects of beta-adrenoreceptor blockers on blood pressure responses to central angiotensin II
- Creators
- W Simon - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyK Schaz - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyJ.F.E Mann - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyU Ganten - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyA.K Johnson - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyTh Unger - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyW Rascher - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of GermanyD Ganten - Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of Germany
- Resource Type
- Journal article
- Publication Details
- Neuropharmacology, Vol.20(8), pp.719-726
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0028-3908(81)90219-7
- PMID
- 6116206
- ISSN
- 0028-3908
- eISSN
- 1873-7064
- Language
- English
- Date published
- 1981
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213426502771
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