Journal article
The effects of deoxycorticosterone-induced sodium appetite on hedonic behaviors in the rat
Behavioral neuroscience, Vol.120(3), pp.571-579
06/2006
DOI: 10.1037/0735-7044.120.3.571
PMID: 16768609
Abstract
The authors tested the hypothesis that chronic treatment with a dose of deoxycorticosterone acetate (DOCA) known to elicit a robust sodium appetite can negatively affect the hedonic state of rats. Daily treatment with DOCA with no opportunity to ingest saline produced a rightward shift in the midpoint (effective current 50) of lateral hypothalamic self-stimulation (LHSS) current-response functions and reduced intakes of a palatable sucrose solution. Providing rats with 0.3 M saline during DOCA treatment prevented the rightward shift in LHSS response functions and the decrease in sucrose intake. The authors concluded that a chronic sodium appetite, with no opportunity to attenuate the appetite, can elicit a reduced responsiveness to reward.
Details
- Title: Subtitle
- The effects of deoxycorticosterone-induced sodium appetite on hedonic behaviors in the rat
- Creators
- Michael J Morris - Department of Psychology, Pharmacology, and Exercise Science, and Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, USAElisa S NaAngela J GrippoAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.120(3), pp.571-579
- DOI
- 10.1037/0735-7044.120.3.571
- PMID
- 16768609
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Grant note
- DK66086 / NIDDK NIH HHS HL57472 / NHLBI NIH HHS HL14388 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2006
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213278002771
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