Journal article
The effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity
Appetite, Vol.116, pp.65-74
09/01/2017
DOI: 10.1016/j.appet.2017.04.008
PMID: 28411128
Abstract
To examine the fetal programming effects of maternal hypertension, natriophilia and hyperreninemia [experimentally induced in rats by partial inter-renal aortic ligature (PAL) prior to mating] fos immunoreactivity was studied in 6-day-old offspring of PAL and control mothers. The purposes of the present set of experiments were twofold. The first was to characterize the effects of PAL on the mother's arterial blood pressure and intake of salt (1.8% NaCl solution) and water over the course of gestation. Second, was to study the pattern of neuronal activation in key brain areas of 6-day-old offspring treated with the dipsogen isoproterenol that were from PAL and control mothers. Beta-adrenergic receptor agonist-treated pups allowed the determination whether there were neuroanatomical correlates within the neural substrates controlling thirst and the enhanced water intake evidenced by the isoproterenol treated pups of PAL mothers. Hydromineral ingestive behavior along with blood pressure and heart rate of PAL (M-PAL) and control (M-sPAL) dams throughout gestation was studied. Higher salt and water intakes along with blood pressures and heart rates were found during gestation and lactation in the M-PAL group. Maternal PAL evoked significantly increased isoproterenol-elicited Fos staining in brain regions (e.g. subfornical organ, organum vasculosum of the lamina terminalis, supraoptic nucleus, hypothalamic paraventricular nucleus and median preoptic nucleus) of 6-day-old pups, which is the age of animals shown enhanced thirst responses in PAL offspring. These results indicate that PAL is compatible with pregnancy, producing a sustained increase in blood pressure and heart rate, along with increased water and salt intake. The present study demonstrates that the neural substrates involved in cardiovascular homeostasis and fluid balance in adult rats are responsive in six-day-old rats, and can be altered by fetal programming.
Details
- Title: Subtitle
- The effects of experimental gestational hypertension on maternal blood pressure and fluid intake and pre-weanling hypothalamic neuronal activity
- Creators
- Juan Arguelles - Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, SpainCarmen Perillan - Departamento de Biología Funcional, Área de Fisiología, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, SpainTerry G Beltz - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, 52242, USABaojian Xue - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, 52242, USADaniel Badaue-Passos - Currently at Departamento de Fisiologia, Centro C. Biológicas e Saúde, Universidade Federal de Sergipe, Sau Cristovao, SE, BrazilJose A Vega - Departamento de Morfologia y Biologia Celular, Universidad de Oviedo, SpainAlan Kim Johnson - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Appetite, Vol.116, pp.65-74
- DOI
- 10.1016/j.appet.2017.04.008
- PMID
- 28411128
- NLM abbreviation
- Appetite
- ISSN
- 0195-6663
- eISSN
- 1095-8304
- Publisher
- Elsevier Ltd
- Grant note
- name: Excellence Mobility Grants; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01 HL14388
- Language
- English
- Date published
- 09/01/2017
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology
- Record Identifier
- 9984002343702771
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