Journal article
The effects of fluticasone propionate on nasal epithelial potential difference
American journal of rhinology, Vol.16(3), pp.145-149
05/2002
DOI: 10.1177/194589240201600304
PMID: 12141771
Abstract
Human airway epithelium maintains homeostasis of the fluid and salt composition at the airway surface by a regulated transport of sodium and chloride ions. The volume and composition of airway surface liquid have been shown to be important in the pathogenesis of cystic fibrosis, nasal inflammatory disease, and nasal polyposis. The presence of functional epithelial sodium and chloride channels in the airway epithelium can be evaluated electrically by measuring the voltage across the nasal epithelium (Vt). Because fluticasone propionate is commonly used to treat nasal inflammatory diseases, we tested its effect on the nasal ion transport.
A single-blind prospective trial was performed on 12 healthy volunteers. Subjects were randomized to receive either fluticasone propionate or normal saline nasal spray twice daily for 2 weeks. We measured the nasal voltage at baseline, days 3 and 14, and 2 weeks after cessation of treatment. The basal voltage, the change in voltage after perfusion with amiloride (sodium channel blocker), and the change in voltage after perfusion with isoproterenol in a low-chloride buffer (chloride channel activator) were recorded. Saccharin clearance times were measured also.
Two-week treatment with fluticasone propionate resulted in a significant increase in the change in Vt after perfusion with amiloride. There was no significant change in the group treated with normal saline. These findings also were observed on day 3 and were reversed completely after the 2-week washout period The increase in amiloride-sensitive Vt did not result in a decrease in mucociliary clearance.
This study suggests that one effect of fluticasone propionate use on nasal mucosa in normal volunteers is increased epithelial sodium absorption.
Details
- Title: Subtitle
- The effects of fluticasone propionate on nasal epithelial potential difference
- Creators
- Scott M Graham - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, USAShaun N ScottJanice LaunspachJoseph Zabner
- Resource Type
- Journal article
- Publication Details
- American journal of rhinology, Vol.16(3), pp.145-149
- Publisher
- United States
- DOI
- 10.1177/194589240201600304
- PMID
- 12141771
- ISSN
- 1050-6586
- eISSN
- 1539-6290
- Grant note
- HL42385 / NHLBI NIH HHS RR00059 / NCRR NIH HHS
- Language
- English
- Date published
- 05/2002
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Neurosurgery; Otolaryngology; Internal Medicine
- Record Identifier
- 9984007299302771
Metrics
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