Journal article
The effects of hyaluronic acid on fibronectin fragment mediated cartilage chondrolysis in skeletally mature rabbits
Osteoarthritis and cartilage, Vol.11(1), pp.44-49
01/2003
DOI: 10.1053/joca.2002.0864
PMID: 12505486
Abstract
Objective Intraarticular Na-Hyaluronate (HA) exerts a beneficial effect on adolescent rabbits after fibronectin fragment (Fn-f) mediated cartilage injury. We extended our studies to a population of rabbits which have reached full skeletal maturity.
Design Adult male NZW rabbits received an injury with Fn-f and no further treatment; an injection of HA followed by Fn-f injury, or Fn-f injury followed by a single or weekly intraarticular injection of HA. All animals were sacrificed 38 days after receiving the Fn-f injury. After sacrifice, proteoglycan (PG) content was determined from articular cartilage from the medial femoral condyles and tibial plateaus. The patellae were processed for histology.
Results Cartilage PG contents were significantly reduced after Fn-f injection (P=0.0167) and were only slightly improved with HA pre-treatment. However, post-treatment with HA resulted in significant improvements in cartilage PG content when compared to Fn-f only (single HA, P=0.01; weekly HA,P =0.01). Loss of Safranin-O staining, cell loss, osteophyte formation and inflammation were present in the patellae following Fn-f injection. Pre-treatment with HA reduced these changes. More significant protection of cartilage and restoration of Fn-f injury were noted in animals receiving post-treatment with HA.
Conclusions These results suggest that 38 days after Fn-f injury the lost PG content induced by Fn-f injection is substantially restored by weekly post-treatment with intraarticular HA in rabbits that have reached full skeletal maturity. Copyright 2003 Published by Elsevier Science Ltd on behalf of OsteoArthritis Research Society International.
Details
- Title: Subtitle
- The effects of hyaluronic acid on fibronectin fragment mediated cartilage chondrolysis in skeletally mature rabbits
- Creators
- J.M Williams - Rush UniversityH Kang - Department of Biochemistry, Rush Medical College at Rush Presbyterian St Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL, 60612-3864, U.S.AV Ummadi - Rush University Medical CenterJian Zhang - University of Iowa, PathologyG.A Homandberg - Rush University Medical Center
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.11(1), pp.44-49
- Publisher
- Elsevier Ltd
- DOI
- 10.1053/joca.2002.0864
- PMID
- 12505486
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Language
- English
- Date published
- 01/2003
- Academic Unit
- Pathology
- Record Identifier
- 9984195953002771
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