Journal article
The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway
Molecular pharmacology, Vol.19(3), pp.470-476
05/1981
DOI: 10.1016/S0026-895X(25)13725-5
PMID: 7266471
Abstract
The effects of methyl mercury on human blood platelets was studied. It induced platelet shape change, platelet aggregation, the platelet release reaction, and the synthesis of malondialdehyde. All of these effects were inhibited by indomethacin, a cyclooxygenase inhibitor. The release reaction and malondialdehyde generation could be induced in the absence of aggregation, and prostaglandin E1 inhibited release but not malondialdehyde production. It is concluded that the activation of arachidonate cycloperoxidation is a plausible and adequate explanation for these effects of methyl mercury, and speculated that the toxic effects of methyl mercury are due to an analogous disturbance of lipid metabolism in other tissue. Methyl mercury also inhibited the prostaglandin E1-stimulated adenylate cyclase of platelets; influenced the rate of uptake of adenosine, adenine, and serotonin, and had minor effects on adenine nucleotide metabolism.
Details
- Title: Subtitle
- The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway
- Creators
- Donald E Macfarlane
- Resource Type
- Journal article
- Publication Details
- Molecular pharmacology, Vol.19(3), pp.470-476
- DOI
- 10.1016/S0026-895X(25)13725-5
- PMID
- 7266471
- ISSN
- 0026-895X
- eISSN
- 1521-0111
- Grant note
- HL 14217 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/1981
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094676202771
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