The effects of naloxone on canine splanchnic arterial smooth muscle

Tomio Sasaki; Neal F Kassell; Donn M Turner; James C Torner; Hans C Coester

doi:10.3181/00379727-177-41967

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The effects of naloxone on canine splanchnic arterial smooth muscle

Journal article

Peer reviewed

The effects of naloxone on canine splanchnic arterial smooth muscle

Tomio Sasaki, Neal F Kassell, Donn M Turner, James C Torner and Hans C Coester

Proceedings of the Society for Experimental Biology and Medicine, Vol.177(3), pp.422-427

12/1984

DOI: 10.3181/00379727-177-41967

PMID: 6514718

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Abstract

The pharmacological properties of naloxone on vascular smooth muscle in vitro were examined using canine mesenteric arterial segments. Naloxone exerted two different effects on the artery: (A) naloxone at a high concentration (3 X 10(-4) M) produced a nonspecific vasodilation; and (B) naloxone at lower concentrations (3 X 10(-7), 3 X 10(-6), and 3 X 10(-5) M) augmented the vasoconstrictor effects of epinephrine and norepinephrine without altering KCl- or serotonin-induced constriction. Naloxone's augmenting effect on epinephrine-induced constriction was dose dependent. Even when the arterial strips were incubated in low calcium (0.8 mM) or calcium free Kreb's solution, naloxone (3 X 10(-5) M) still augmented epinephrine-induced constriction. With respect to naloxone's effect on another alpha-adrenoreceptor agonist, naloxone (3 X 10(-5) M) failed to alter phenylephrine-induced constriction. Naloxone's augmenting effect on norepinephrine-induced constriction was abolished when the specimens were incubated with 10(-5) M normetanephrine, while naloxone (3 X 10(-5) M) still augmented the constriction even when the specimens were incubated with 10(-5) M cocaine. These results suggest that naloxone at lower concentrations may augment the constrictor responses to catecholamines, at least in part, by inhibiting the extraneuronal uptake of those catecholamines.

Norepinephrine - pharmacology

Calcium - pharmacology

Male

Serotonin - pharmacology

Vasoconstriction - drug effects

Cocaine - pharmacology

Animals

Drug Interactions

Muscle Contraction - drug effects

Naloxone - pharmacology

Potassium Chloride - pharmacology

Dogs

Mesenteric Arteries

Female

Vasodilation - drug effects

Epinephrine - pharmacology

Muscle, Smooth, Vascular - physiology

Muscle, Smooth, Vascular - drug effects

Details

Title: Subtitle: The effects of naloxone on canine splanchnic arterial smooth muscle
Creators: Tomio Sasaki
Neal F Kassell
Donn M Turner
James C Torner
Hans C Coester
Resource Type: Journal article
Publication Details: Proceedings of the Society for Experimental Biology and Medicine, Vol.177(3), pp.422-427
DOI: 10.3181/00379727-177-41967
PMID: 6514718
NLM abbreviation: Proc Soc Exp Biol Med
ISSN: 0037-9727
eISSN: 1525-1373
Publisher: United States
Language: English
Date published: 12/1984
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995152302771

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