Journal article
The effects of pentoxifylline on skeletal muscle contractility and neuromuscular transmission during hypoxia
Indian journal of pharmacology, Vol.41(5), pp.213-217
10/2009
DOI: 10.4103/0253-7613.58509
PMCID: PMC2812779
PMID: 20177491
Abstract
Objectives: The objective of this study was to investigate the effects of pentoxifylline (PTX), a drug that is mainly used for indications related to tissue hypoxia, on hypoxia-induced inhibition of skeletal muscle contractility and neuromuscular transmission in mice. We hypothesized that chronic PTX treatment alters skeletal muscle contractility and hypoxia-induced dysfunction.
Materials and methods: Mice were treated with 50 mg/kg PTX or saline intraperitoneally for a week. Following ether anesthesia, diaphragm muscles were removed; isometric muscle contractions and action potentials were recorded. Time to reach neuromuscular blockade and the rate of recovery of muscle contractility were assessed during hypoxia and re-oxygenation.
Results: The PTX group displayed 90% greater twitch amplitudes (P < 0.01). Hypoxia depressed twitch contractions and caused neuromuscular blockade in both groups. However, neuromuscular blockade occurred earlier in PTX-treated animals (P < 0.05). Muscle contractures developed during hypoxia were more pronounced in the PTX group (P < 0.05). Re-oxygenation reduced contracture and indirect muscle contractions resumed. The rate of recovery of contractions was faster (P < 0.05) and the amplitude of contractions was greater (P < 0.01) in the PTX group. PTX treatment increased amplitude (P < 0.05) and shortened action potential (P < 0.05) without altering resting membrane potential, excitation threshold, and neurotransmitter release.
Conclusion: Chronic PTX treatment increases diaphragm contractility, but amplifies hypoxia-induced contractile dysfunction in mice. These results may implicate important clinical consequences for clinical usage of PTX in hypoxia-related conditions.
Details
- Title: Subtitle
- The effects of pentoxifylline on skeletal muscle contractility and neuromuscular transmission during hypoxia
- Creators
- Fatma Simsek-Duran - Department of Pharmacology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, TurkeyMert Ertunc - Department of Pharmacology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, TurkeyRustu Onur - Department of Pharmacology, Faculty of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey
- Resource Type
- Journal article
- Publication Details
- Indian journal of pharmacology, Vol.41(5), pp.213-217
- DOI
- 10.4103/0253-7613.58509
- PMID
- 20177491
- PMCID
- PMC2812779
- NLM abbreviation
- Indian J Pharmacol
- ISSN
- 0253-7613
- eISSN
- 1998-3751
- Publisher
- Medknow Publications; India
- Language
- English
- Date published
- 10/2009
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003972602771
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