Journal article
The energetics of small internal loops in RNA
Biopolymers, Vol.52(4), pp.157-167
1999
DOI: 10.1002/1097-0282(1999)52:4<157::AID-BIP1001>3.0.CO;2-E
PMID: 11295748
Abstract
The energetics of small internal loops are important for prediction of RNA secondary and tertiary structure, selection of drug target sites, and understanding RNA structure–function relationships. Hydrogen bonding, base stacking, electrostatic interactions, backbone distortion, and base-pair size compatibility all contribute to the energetics of small internal loops. Thus, the sequence dependence of these energetics are idiosyncratic. Current approximations for predicting the free energies of internal loops consider size, asymmetry, closing base pairs, and the potential to form GA, GG, or UU pairs. The database of known three-dimensional structures allows for comparison with the models used for predicting stability from sequence.
Details
- Title: Subtitle
- The energetics of small internal loops in RNA
- Creators
- Susan J. Schroeder - University of RochesterMark E. Burkard - University of RochesterDouglas H. Turner - University of Rochester
- Resource Type
- Journal article
- Publication Details
- Biopolymers, Vol.52(4), pp.157-167
- Publisher
- John Wiley & Sons, Inc
- DOI
- 10.1002/1097-0282(1999)52:4<157::AID-BIP1001>3.0.CO;2-E
- PMID
- 11295748
- ISSN
- 0006-3525
- eISSN
- 1097-0282
- Number of pages
- 11
- Language
- English
- Date published
- 1999
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984701254102771
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