Journal article
The engine driving the ship: metabolic steering of cell proliferation and death
Nature reviews. Molecular cell biology, Vol.11(10), pp.715-727
10/01/2010
DOI: 10.1038/nrm2972
PMID: 20861880
Abstract
Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it is not fully understood how metabolic pathways such as glycolysis and the pentose phosphate pathway communicate to cell cycle and apoptotic effectors, it is clear that a complex network of signalling molecules is required to integrate metabolic inputs. D-type cyclins, cyclin-dependent kinases, the anaphase-promoting complex, p53, caspase 2 and B cell lymphoma 2 proteins, among others, have been shown to be regulated by metabolic crosstalk. Elucidating these pathways is of great importance, as metabolic aberrations and their downstream effects are known to contribute to the aetiology of cancer and degenerative disorders.
Details
- Title: Subtitle
- The engine driving the ship: metabolic steering of cell proliferation and death
- Creators
- Marisa R. Buchakjian - Duke UniversitySally Kornbluth - Duke University
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Molecular cell biology, Vol.11(10), pp.715-727
- Publisher
- Springer Nature
- DOI
- 10.1038/nrm2972
- PMID
- 20861880
- ISSN
- 1471-0072
- eISSN
- 1471-0080
- Number of pages
- 13
- Language
- English
- Date published
- 10/01/2010
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984311446902771
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