Journal article
The enigmatic role of the hemochromatosis protein (HFE) in iron absorption
Trends in molecular medicine, Vol.9(3), pp.118-125
03/01/2003
DOI: 10.1016/S1471-4914(03)00023-6
PMID: 12657433
Abstract
The
HFE gene, a member of the class-I transplantation antigen gene family, is responsible for hereditary hemochromatosis, one of the most common inherited diseases in individuals of European descent. Patients exhibit predictable changes in iron homeostasis, including elevations in both transferrin saturation and serum ferritin levels. A subset of patients progress to overt clinical sequelae, resulting from iron overload. A hallmark of the disease is increased absorption of iron by the intestine. Although the HFE protein appears to modulate the function of the transferrin receptor
in vitro, its precise role
in vivo remains obscure. With multiple cell types involved in iron metabolism, the function of HFE is likely to be complex.
Details
- Title: Subtitle
- The enigmatic role of the hemochromatosis protein (HFE) in iron absorption
- Creators
- Michael J. Chorney - Pennsylvania State UniversityYukinori Yoshida - Pennsylvania State UniversityPaul N. Meyer - Pennsylvania State UniversityMika Yoshida - Pennsylvania State UniversityGlenn S. Gerhard - Dept of Pathology, Dartmouth Medical School, Hanover, NH 03755, USA
- Resource Type
- Journal article
- Publication Details
- Trends in molecular medicine, Vol.9(3), pp.118-125
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S1471-4914(03)00023-6
- PMID
- 12657433
- ISSN
- 1471-4914
- eISSN
- 1471-499X
- Number of pages
- 8
- Language
- English
- Date published
- 03/01/2003
- Academic Unit
- Pathology
- Record Identifier
- 9984822979802771
Metrics
1 Record Views