Journal article
The epidemiology and outcomes of invasive Candida infections among organ transplant recipients in the United States: results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)
Transplant infectious disease, Vol.18(6), pp.921-931
12/2016
DOI: 10.1111/tid.12613
PMID: 27643395
Abstract
Background
Invasive candidiasis (IC) is a common cause of mortality in solid organ transplant recipients (OTRs), but knowledge of epidemiology in this population is limited.
Method
The present analysis describes data from 15 US centers that prospectively identified IC from nearly 17 000 OTRs. Analyses were undertaken to determine predictors of infection and mortality.
Results
A total of 639 cases of IC were identified. The most common species was Candida albicans (46.3%), followed by Candida glabrata (24.4%) and Candida parapsilosis (8.1%). In 68 cases >1 species was identified. The most common infection site was bloodstream (44%), followed by intra‐abdominal (14%). The most frequently affected allograft groups were liver (41.1%) and kidney (35.3%). All‐cause mortality at 90 days was 26.5% for all species and was highest for Candida tropicalis (44%) and C. parapsilosis (35.2%). Non‐white race and female gender were more commonly associated with non‐albicans species. A high rate of breakthrough IC was seen in patients receiving antifungal prophylaxis (39%). Factors associated with mortality include organ dysfunction, lung transplant, and treatment with a polyene antifungal. The only modifiable factor identified was choice of antifungal drug class based upon infecting Candida species.
Conclusion
These data highlight the common and distinct features of IC in OTRs.
Details
- Title: Subtitle
- The epidemiology and outcomes of invasive Candida infections among organ transplant recipients in the United States: results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)
- Creators
- David R Andes - University of WisconsinNasia Safdar - University of WisconsinJohn W Baddley - University of Alabama at BirminghamBarbara Alexander - Duke University School of MedicineLisa Brumble - Mayo ClinicAllison Freifeld - University of NebraskaSusan Hadley - Tufts UniversityLoreen Herwaldt - University of Iowa School of MedicineCarol Kauffman - Michigan University School of MedicineG. Marshall Lyon - Emory UniversityVicki Morrison - University of Minnesota School of MedicineThomas Patterson - University of Texas at San AntonioTrish Perl - Johns Hopkins UniversityRandall Walker - Mayo ClinicTim Hess - University of WisconsinTom Chiller - Centers for Disease Control and PreventionPeter G Pappas - University of Alabama at BirminghamTRANSNET Investigators
- Resource Type
- Journal article
- Publication Details
- Transplant infectious disease, Vol.18(6), pp.921-931
- DOI
- 10.1111/tid.12613
- PMID
- 27643395
- NLM abbreviation
- Transpl Infect Dis
- ISSN
- 1398-2273
- eISSN
- 1399-3062
- Number of pages
- 11
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Infectious Diseases; Epidemiology; Internal Medicine
- Record Identifier
- 9984094210002771
Metrics
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