The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus

Henry D Appelman; Catherine Streutker; Michael Vieth; Helmut Neumann; Markus F Neurath; Melissa P Upton; Xavier Sagaert; Helen H Wang; Hala El-Zimaity; Susan C Abraham; Andrew M Bellizzi

doi:10.1111/nyas.12241

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The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus

Journal article

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The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus

Henry D Appelman, Catherine Streutker, Michael Vieth, Helmut Neumann, Markus F Neurath, Melissa P Upton, Xavier Sagaert, Helen H Wang, Hala El-Zimaity, Susan C Abraham, …

Annals of the New York Academy of Sciences, Vol.1300(1), pp.144-165

10/2013

DOI: 10.1111/nyas.12241

PMID: 24117640

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Abstract

This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are identified in the squamous esophagus; dilated intercellular spaces; the metastasizing potential of early carcinoma-dependent, molecular or immunohistochemical tests that improve diagnosis; the role of immunohistochemistry IHC in grading of neoplasia in Barrett's esophagus and defining the risk of progression to adenocarcinoma; the roles of CDX1 and CDX2 in squamous and cardiac mucosa; and the role of desmosomal cadherins and lectins in squamous and cardiac mucosa.

Immunohistochemistry

Barrett Esophagus - metabolism

Esophagus - pathology

Gastroesophageal Reflux - metabolism

Mucous Membrane - pathology

Barrett Esophagus - pathology

Gastroesophageal Reflux - diagnosis

Gastroesophageal Reflux - pathology

Humans

Esophagus - metabolism

Barrett Esophagus - diagnosis

Mucous Membrane - metabolism

Details

Title: Subtitle: The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus
Creators: Henry D Appelman - Department of Pathology, University of Michigan, Ann Arbor, Michigan
Catherine Streutker - St. Michael's Hospital, Toronto, Canada
Michael Vieth - Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
Helmut Neumann - Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
Markus F Neurath - Department of Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
Melissa P Upton - Department of Pathology, University of Washington, Seattle, Washington
Xavier Sagaert - Department of Pathology, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium
Helen H Wang - Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
Hala El-Zimaity - Toronto General Hospital, Toronto, Ontario
Susan C Abraham - Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
Andrew M Bellizzi - Department of Pathology, University of Iowa Hospitals and Clinics, University of Iowa Carver College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Annals of the New York Academy of Sciences, Vol.1300(1), pp.144-165
DOI: 10.1111/nyas.12241
PMID: 24117640
NLM abbreviation: Ann N Y Acad Sci
ISSN: 0077-8923
eISSN: 1749-6632
Publisher: Wiley; United States
Language: English
Date published: 10/2013
Academic Unit: Pathology
Record Identifier: 9984047668402771

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