Journal article
The evolving landscape of glioblastoma stem cells
Current opinion in neurology, Vol.26(6), pp.701-707
12/01/2013
DOI: 10.1097/WCO.0000000000000032
PMCID: PMC4031658
PMID: 24152818
Abstract
Purpose of review Recent advances in the role of cancer stem cells (CSCs) in glioblastoma will be reviewed.
Recent findings In the decade since the description of brain tumor CSCs, the potential significance of these cells in tumor growth, therapeutic resistance, and spread has become evident. Most recently, the interplay between CSCs, tumor genetics, and the microenvironment has offered potential nodes of fragility under therapeutic development. The CSC phenotype is informed by specific receptor signaling, and study of the regulation of stem cell genes by transcription factors and microRNAs has identified a number of new targets amenable to treatment. Like normal stem cells, CSCs display specific epigenetic landscapes and metabolic profiles.
Summary Brain cancers activate core stem cell regulatory pathways to empower self-renewal, maintenance of an organ system (albeit an aberrant one), and survival under stress that collectively permits tumor growth, therapeutic resistance, invasion, and angiogenesis. These properties have implicated CSCs as contributors in GBM progression and recurrence, spurring a search for anti-CSC therapies that do not disrupt normal stem cell maintenance. The last year has witnessed a rapid evolution in the understanding of CSC biology to inform preclinical targeting.
Details
- Title: Subtitle
- The evolving landscape of glioblastoma stem cells
- Creators
- Kenneth Yan - Cleveland Clin, Dept Stem Cell Biol & Regenerat Med, Lerner Res Inst, Cleveland, OH 44106 USAKailin Yang - Cleveland Clin, Dept Stem Cell Biol & Regenerat Med, Lerner Res Inst, Cleveland, OH 44106 USAJeremy N. Rich - Cleveland Clinic Lerner College of Medicine
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurology, Vol.26(6), pp.701-707
- DOI
- 10.1097/WCO.0000000000000032
- PMID
- 24152818
- PMCID
- PMC4031658
- NLM abbreviation
- Curr Opin Neurol
- ISSN
- 1350-7540
- eISSN
- 1473-6551
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- James S. McDonnell Foundation Research Programs Committees of Cleveland Clinic American Brain Tumor Association TL1TR000441 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) T32GM007250 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) CA154130; CA1129958 / The National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01CA129958 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 12/01/2013
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984696579502771
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