Journal article
The functional importance of multiple actin isoforms
BioEssays, Vol.12(7), pp.309-315
07/1990
DOI: 10.1002/bies.950120702
PMID: 2203335
Abstract
Actin is a protein that plays an important role in cell structure, cell motility, and the generation of contractile force in both muscle and nonmuscle cells. In many organisms, multiple forms of actin, or isoactins, are found. These are products of different genes and have different, although very similar, amino acid sequences. Furthermore, these isoactins are expressed in a tissue specific fashion that is conserved across species, suggesting that their presence is functionally important and their behavior can be distinguished quantitatively from one another in vitro. In muscle cells, they are differentially distributed within the cell and some are specifically associated with structures such as costameres, mitochondria, and neuromuscular junctions. There is also good evidence for specific isoactin function in microvascular pericytes and in the intestinal brush border. However, the necessity of specific isoactins for various functions has not yet been conclusively demonstrated.
Details
- Title: Subtitle
- The functional importance of multiple actin isoforms
- Creators
- Peter A Rubenstein
- Resource Type
- Journal article
- Publication Details
- BioEssays, Vol.12(7), pp.309-315
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- DOI
- 10.1002/bies.950120702
- PMID
- 2203335
- ISSN
- 0265-9247
- eISSN
- 1521-1878
- Number of pages
- 7
- Language
- English
- Date published
- 07/1990
- Academic Unit
- Stead Family Department of Pediatrics; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984024557902771
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