The functional neural architecture of dysfunctional reward processing in autism

Hildegard Janouschek; Henry W Chase; Rachel J Sharkey; Zeru J Peterson; Julia A Camilleri; Ted Abel; Simon B Eickhoff; Thomas Nickl-Jockschat

doi:10.1016/j.nicl.2021.102700

Back

The functional neural architecture of dysfunctional reward processing in autism

Journal article

Open access

Peer reviewed

The functional neural architecture of dysfunctional reward processing in autism

Hildegard Janouschek, Henry W Chase, Rachel J Sharkey, Zeru J Peterson, Julia A Camilleri, Ted Abel, Simon B Eickhoff and Thomas Nickl-Jockschat

NeuroImage clinical, Vol.31, 102700

05/2021

DOI: 10.1016/j.nicl.2021.102700

PMCID: PMC8239466

PMID: 34161918

Files and links (1)

url

https://doi.org/10.1016/j.nicl.2021.102700View

Published (Version of record) Open Access

Abstract

Functional imaging studies have found differential neural activation patterns during reward-paradigms in patients with autism spectrum disorder (ASD) compared to neurotypical controls. However, publications report conflicting results on the directionality and location of these aberrant activations. We here quantitatively summarized relevant fMRI papers in the field using the anatomical likelihood estimation (ALE) algorithm. Patients with ASD consistently showed hypoactivations in the striatum across studies, mainly in the right putamen and accumbens. These regions are functionally involved in the processing of rewards and are enrolled in extensive neural networks involving limbic, cortical, thalamic and mesencephalic regions. The striatal hypo-activations found in our ALE meta-analysis, which pooled over contrasts derived from the included studies on reward-processing in ASD, highlight the role of the striatum as a key neural correlate of impaired reward processing in autism. These changes were present for studies using social and non-social stimuli alike. The involvement of these regions in extensive networks associated with the processing of both positive and negative emotion alike might hint at broader impairments of emotion processing in the disorder.

Details

Title: Subtitle: The functional neural architecture of dysfunctional reward processing in autism
Creators: Hildegard Janouschek
Henry W Chase
Rachel J Sharkey
Zeru J Peterson
Julia A Camilleri
Ted Abel
Simon B Eickhoff
Thomas Nickl-Jockschat
Resource Type: Journal article
Publication Details: NeuroImage clinical, Vol.31, 102700
DOI: 10.1016/j.nicl.2021.102700
PMID: 34161918
PMCID: PMC8239466
NLM abbreviation: Neuroimage Clin
ISSN: 2213-1582
eISSN: 2213-1582
Language: English
Date published: 05/2021
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984082390502771

Metrics

20 Record Views

30 Times Cited - Web of Science