Journal article
The generation and modulation of antigen-specific memory CD8 T cell responses
Journal of leukocyte biology, Vol.80(1), pp.16-23
07/2006
DOI: 10.1189/jlb.0206118
PMID: 16684891
Abstract
The immune system has adapted to effect different mechanisms to combat the multitude of potential pathogens in our environment. In particular, CD8 T cells are participants in the immune response to intracellular pathogens, which include viruses, certain types of bacteria, and protozoa. Classified as members of the adaptive immune system, antigen-specific CD8 T cells after activation eventually form a pool of memory. Memory cells have an enhanced ability to protect against subsequent infections. The generation of antigen-specific CD8 T cells, therefore, is a potential approach in the design of vaccines, especially for those pathogens in which the humoral response is insufficient to protect the host.
Details
- Title: Subtitle
- The generation and modulation of antigen-specific memory CD8 T cell responses
- Creators
- Ali Jabbari - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, 52242, USAJohn T Harty
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.80(1), pp.16-23
- Publisher
- United States
- DOI
- 10.1189/jlb.0206118
- PMID
- 16684891
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Grant note
- T32 GM007337 / NIGMS NIH HHS
- Language
- English
- Date published
- 07/2006
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984025466902771
Metrics
30 Record Views