Journal article
The genetic architecture of the human cerebral cortex
Science (American Association for the Advancement of Science), Vol.367(6484), pp.eaay6690-Grasby , K L , Jahanshad , N , Painter , J N , Colodro-conde , L , Bralten , J , Hibar , D P , Lind , P A , Pizzagalli , F , Ching , C R K , Mcmahon , M A B , Shatokhina , N , Zsembik , L C P , Thomopoulos , S I , Zhu , A H , Strike , L T , Agartz , I , Alhusaini , S , Almeida , M A A , Alnæs , D , Amlien , I K , Andersson , M , Ard , T , Armstrong , N J , Ashley-koch , A , Atkins , J R , Bernard , M , Brouwer , R M , Buimer , E E L , Bülow , R , Bürger , C , Cannon , D M , Chakravarty , M , Chen , Q , Cheung , J W , Couvy-duchesne , B , Dale , A M , Dalvie , S , De Araujo , T K , De Zubicaray , G I , De Zwarte , S M C , Den Braber , A , Doan , N T , Dohm , K , Ehrlich , S , Engelbrecht , H , Erk , S , Fan , C C , Fedko , I O , Foley , S F , Ford , J M , Fukunaga , M , Garrett , M E , Ge , T , Giddaluru , S , Goldman , A L , Green , M J , Groenewold , N A , Grotegerd , D , Gurholt , T P , Gutman , B A , Hansell , N K , Harris , M A , Harrison , M B , Haswell , C C , Hauser , M , Herms , S , Heslenfeld , D J , Ho , N F , Hoehn , D , Hoffmann , P , Holleran , L , Hoogman , M , Hottenga , J , Ikeda , M , Janowitz , D , Jansen , I E , Jia , T , Jockwitz , C , Kanai , R , Karama , S , Kasperaviciute , D , Kaufmann , T , Kelly , S , Kikuchi , M , Klein , M , Knapp , M , Knodt , A R , Krämer , B , Lam , M , Lancaster , T M , Lee , P H , Lett , T A , Lewis , L B , Lopes-cendes , I , Luciano , M , Macciardi , F , Marquand , A F , Mathias , S R , Melzer , T R , Milaneschi , Y , Mirza-schreiber , N , Moreira , J C V , Mühleisen , T W , Müller-myhsok , B , Najt , P , Nakahara , S , Nho , K , Olde Loohuis , L M , Orfanos , D P , Pearson , J F , Pitcher , T L , Pütz , B , Quidé , Y , Ragothaman , A , Rashid , F M , Reay , W R , Redlich , R , Reinbold , C S , Repple , J , Richard , G , Riedel , B C , Risacher , S L , Rocha , C S , Mota , N R , Salminen , L , Saremi , A , Saykin , A J , Schlag , F , Schmaal , L , Schofield , P R , Secolin , R , Shapland , C Y , Shen , L , Shin , J , Shumskaya , E , Sønderby , I E , Sprooten , E , Tansey , K E , Teumer , A , Thalamuthu , A , Tordesillas-gutiérrez , D , Turner , J A , Uhlmann , A , Vallerga , C L , Van Der Meer , D , Van Donkelaar , M M J , Van Eijk , L , Van Erp , T G M , Van Haren , N E M , Van Rooij , D , Van Tol , M , Veldink , J H , Verhoef , E , Walton , E , Wang , M , Wang , Y , Wardlaw , J M , Wen , W , Westlye , L T , Whelan , C D , Witt , S H , Wittfeld , K , Wolf , C , Wolfers , T , Wu , J Q , Yasuda , C L , Zaremba , D , Zhang , Z , Zwiers , M P , Artiges , E , Assareh , A A , Ayesa-arriola , R , Belger , A , Brandt , C L , Brown , G G , Cichon , S , Curran , J E , Davies , G E , Degenhardt , F , Dennis , M F , Dietsche , B , Djurovic , S , Doherty , C P , Espiritu , R , Garijo , D , Gil , Y , Gowland , P A , Green , R C , Häusler , A N , Heindel , W , Ho , B , Hoffmann , W U , Holsboer , F , Homuth , G , Hosten , N , Jack , C R , Jang , M , Jansen , A , Kimbrel , N A , Kolskår , K , Koops , S , Krug , A , Lim , K O , Luykx , J J , Mathalon , D H , Mather , K A , Mattay , V S , Matthews , S , Mayoral Van Son , J , Mcewen , S C , Melle , I , Morris , D W , Mueller , B A , Nauck , M , Nordvik , J E , Nöthen , M M , O’leary , D S , Opel , N , Martinot , M P , Pike , G B , Preda , A , Quinlan , E B , Rasser , P E , Ratnakar , V , Reppermund , S , Steen , V M , Tooney , P A , Torres , F R , Veltman , D J , Voyvodic , J T , Whelan , R , White , T , Yamamori , H , Adams , H H H , Bis , J C , Debette , S , Decarli , C , Fornage , M , Gudnason , V , Hofer , E , Ikram , M A , Launer , L , Longstreth , W T , Lopez , O L , Mazoyer , B , Mosley , T H , Roshchupkin , G V , Satizabal , C L , Schmidt , R , Seshadri , S , Yang , Q , Alvim , M K M , Ames , D , Anderson , T J , Andreassen , O A , Arias-vasquez , A , Bastin , M E , Baune , B T , Beckham , J C , Blangero , J , Boomsma , D I , Brodaty , H , Brunner , H G , Buckner , R L , Buitelaar , J K , Bustillo , J R , Cahn , W , Cairns , M J , Calhoun , V , Carr , V J , Caseras , X , Caspers , S , Cavalleri , G L , Cendes , F , Corvin , A , Crespo-facorro , B , Dalrymple-alford , J C , Dannlowski , U , De Geus , E J C , Deary , I J , Delanty , N , Depondt , C , Desrivières , S , Donohoe , G , Espeseth , T , Fernández , G , Fisher , S E , Flor , H , Forstner , A J , Francks , C , Franke , B , Glahn , D C , Gollub , R L , Grabe , H J , Gruber , O , Håberg , A K , Hariri , A R , Hartman , C A , Hashimoto , R , Heinz , A , Henskens , F A , Hillegers , M H J , Hoekstra , P J , Holmes , A J , Hong , L E , Hopkins , W D , Hulshoff Pol , H E , Jernigan , T L , Jönsson , E G , Kahn , R S , Kennedy , M A , Kircher , T T J , Kochunov , P , Kwok , J B J , Le Hellard , S , Loughland , C M , Martin , N G , Martinot , J , Mcdonald , C , Mcmahon , K L , Meyer-lindenberg , A , Michie , P T , Morey , R A , Mowry , B , Nyberg , L , Oosterlaan , J , Ophoff , R A , Pantelis , C , Paus , T , Pausova , Z , Penninx , B W J H , Polderman , T J C , Posthuma , D , Rietschel , M , Roffman , J L , Rowland , L M , Sachdev , P S , Sämann , P G , Schall , U , Schumann , G , Scott , R J , Sim , K , Sisodiya , S M , Smoller , J W , Sommer , I E , St Pourcain , B , Stein , D J , Toga , A W , Trollor , J N , Van Der Wee , N J A , Van ’t Ent , D , Völzke , H , Walter , H , Weber , B , Weinberger , D R , Wright , M J , Zhou , J , Stein , J L , Thompson , P M & Medland , S E 2020 , ' The genetic architecture of the human cerebral cortex ' , Science , vol. 367 , no. 6484 , pp. eaay6690 . https://doi.org/10.1126/science.aay6690
03/20/2020
DOI: 10.1126/science.aay6690
PMID: 32193296
Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson’s disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
Details
- Title: Subtitle
- The genetic architecture of the human cerebral cortex
- Creators
- Katrina L Grasby - Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaNeda Jahanshad - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USADaniel S O’Leary - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, USAJodie N Painter - Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaLucía Colodro-Conde - Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., School of Psychology, University of Queensland, Brisbane, QLD, Australia., School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Faculty of Psychology, University of Murcia, Murcia, SpainJanita Bralten - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NetherlandsDerrek P Hibar - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Personalized Healthcare, Genentech, Inc., South San Francisco, CA, USAPenelope A Lind - Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia., Faculty of Medicine, University of Queensland, Brisbane, QLD, AustraliaFabrizio Pizzagalli - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAChristopher R. K Ching - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Graduate Interdepartmental Program in Neuroscience, University of California Los Angeles, Los Angeles, CA, USAMary Agnes B McMahon - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USANatalia Shatokhina - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USALeo C. P Zsembik - Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USASophia I Thomopoulos - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAAlyssa H Zhu - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USALachlan T Strike - Queensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaIngrid Agartz - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway., Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenSaud Alhusaini - Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Neurology Department, Yale School of Medicine, New Haven, CT, USAMarcio A. A Almeida - Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USAInge K Amlien - Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, NorwayDag Alnæs - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayMicael Andersson - Department of Integrative Medical Biology, Umeå University, Umeå, Sweden., Umeå Center for Functional Brain Imaging, Umeå University, Umeå, SwedenTyler Ard - Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USANicola J Armstrong - Mathematics and Statistics, Murdoch University, Murdoch, WA, AustraliaAllison Ashley-Koch - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USAJoshua R Atkins - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Priority Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, AustraliaManon Bernard - The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaRachel M Brouwer - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsElizabeth E. L Buimer - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsRobin Bülow - Institute for Radiology and Neuroradiology, University Medicine, Ernst-Moritz-Arndt University, Greifswald, GermanyChristian Bürger - Department of Psychiatry, University of Münster, Münster, GermanyDara M Cannon - Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, IrelandMallar Chakravarty - Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, QC, CanadaQiang Chen - Lieber Institute for Brain Development, Baltimore, MD, USAJoshua W Cheung - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USABaptiste Couvy-Duchesne - Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaAnders M Dale - Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA., Department of Radiology, University of California San Diego, San Diego, CA, USAShareefa Dalvie - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South AfricaTânia K de Araujo - Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Brazil., BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, BrazilGreig I de Zubicaray - Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaSonja M. C de Zwarte - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsAnouk den Braber - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, NetherlandsNhat Trung Doan - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayKatharina Dohm - Department of Psychiatry, University of Münster, Münster, GermanyStefan Ehrlich - Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, GermanyHannah-Ruth Engelbrecht - Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South AfricaSusanne Erk - Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyChun Chieh Fan - Department of Cognitive Science, University of California San Diego, San Diego, CA, USAIryna O Fedko - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsSonya F Foley - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UKJudith M Ford - San Francisco Veterans Administration Medical Center, San Francisco, CA, USAMasaki Fukunaga - Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, JapanMelanie E Garrett - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USATian Ge - Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USASudheer Giddaluru - NORMENT - K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, NorwayAaron L Goldman - Lieber Institute for Brain Development, Baltimore, MD, USAMelissa J Green - School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Neuroscience Research Australia, Sydney, NSW, AustraliaNynke A Groenewold - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South AfricaDominik Grotegerd - Department of Psychiatry, University of Münster, Münster, GermanyTiril P Gurholt - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, NorwayBoris A Gutman - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USANarelle K Hansell - Queensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaMathew A Harris - Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Division of Psychiatry, University of Edinburgh, Edinburgh, UKMarc B Harrison - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USACourtney C Haswell - Duke UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA., Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham VA Medical Center, Durham, NC, USAMichael Hauser - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USAStefan Herms - Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, GermanyDirk J Heslenfeld - Department of Cognitive and Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsNew Fei Ho - Research Division, Institute of Mental Health, Singapore, SingaporeDavid Hoehn - Max Planck Institute of Psychiatry, Munich, GermanyPer Hoffmann - Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, GermanyLaurena Holleran - Centre for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland Galway, Galway, IrelandMartine Hoogman - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NetherlandsJouke-Jan Hottenga - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsMasashi Ikeda - Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, JapanDeborah Janowitz - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyIris E Jansen - Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Department of Neurology, Alzheimer Center, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsTianye Jia - Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China., Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China., Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UKChristiane Jockwitz - Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen University, Aachen, Germany., JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, GermanyRyota Kanai - Department of Neuroinformatics, Araya, Inc., Tokyo, Japan., Sackler Centre for Consciousness Science, School of Psychology, University of Sussex, Falmer, UK., Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, JapanSherif Karama - Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Department of Psychiatry, McGill University, Montreal, QC, Canada., McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, QC, CanadaDalia Kasperaviciute - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Genomics England, Queen Mary University of London, London, UKTobias Kaufmann - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwaySinead Kelly - Public Psychiatry Division, Massachusetts Mental Health Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USAMasataka Kikuchi - Department of Genome Informatics, Graduate School of Medicine, Osaka University, Suita, JapanMarieke Klein - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsMichael Knapp - Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, GermanyAnnchen R Knodt - Department of Psychology and Neuroscience, Duke University, Durham, NC, USABernd Krämer - Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany., Centre for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, GermanyMax Lam - Research Division, Institute of Mental Health, Singapore, Singapore., Human Genetics, Genome Institute of Singapore, Singapore, SingaporeThomas M Lancaster - Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK., MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKPhil H Lee - Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Department of Psychiatry, Harvard Medical School, Boston, MA, USATristram A Lett - Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyLindsay B Lewis - McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, QC, Canada., McGill Centre for Integrative Neuroscience, McGill University, Montreal, QC, CanadaIscia Lopes-Cendes - Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Brazil., BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, BrazilMichelle Luciano - Department of Psychology, University of Edinburgh, Edinburgh, UK., Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UKFabio Macciardi - Department of Psychiatry and Human Behavior, School of Medicine University of California, Irvine, Irvine, CA, USAAndre F Marquand - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, NetherlandsSamuel R Mathias - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USAYuri Milaneschi - Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, NetherlandsTracy R Melzer - Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand., New Zealand Brain Research Institute, Christchurch, New Zealand., Brain Research New Zealand - Rangahau Roro Aotearoa, Christchurch, New ZealandNazanin Mirza-Schreiber - Max Planck Institute of Psychiatry, Munich, Germany., Institute of Neurogenomics, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, GermanyJose C. V Moreira - BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., IC - Institute of Computing, Campinas, BrazilThomas W Mühleisen - Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., Cécile and Oskar Vogt Institute of Brain Research, Medical Faculty, Heinrich Heine University, Düsseldorf, GermanyBertram Müller-Myhsok - Max Planck Institute of Psychiatry, Munich, Germany., Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Institute of Translational Medicine, Liverpool, UKPablo Najt - Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, IrelandSoichiro Nakahara - Department of Psychiatry and Human Behavior, School of Medicine University of California, Irvine, Irvine, CA, USA., Drug Discovery Research, Astellas Pharmaceuticals, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, JapanKwangsik Nho - Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USALoes M Olde Loohuis - Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USADimitri Papadopoulos Orfanos - NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, FranceJohn F Pearson - Biostatistics and Computational Biology Unit, University of Otago, Christchurch, Christchurch, New Zealand., Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch, New ZealandToni L Pitcher - Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand., New Zealand Brain Research Institute, Christchurch, New Zealand., Brain Research New Zealand - Rangahau Roro Aotearoa, Christchurch, New ZealandBenno Pütz - Max Planck Institute of Psychiatry, Munich, GermanyYann Quidé - School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Neuroscience Research Australia, Sydney, NSW, AustraliaAnjanibhargavi Ragothaman - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAFaisal M Rashid - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAWilliam R Reay - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Priority Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, AustraliaRonny Redlich - Department of Psychiatry, University of Münster, Münster, GermanyCéline S Reinbold - Centre for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway., Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, SwitzerlandJonathan Repple - Department of Psychiatry, University of Münster, Münster, GermanyGeneviève Richard - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Department of Psychology, University of Oslo, Oslo, Norway., Sunnaas Rehabilitation Hospital HT, Nesodden, NorwayBrandalyn C Riedel - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USAShannon L Risacher - Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USACristiane S Rocha - Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Brazil., BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, BrazilNina Roth Mota - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Psychiatry, Radboud university medical center, Nijmegen, NetherlandsLauren Salminen - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAArvin Saremi - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAAndrew J Saykin - Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USAFenja Schlag - Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsLianne Schmaal - Orygen, The National Centre of Excellence for Youth Mental Health, Melbourne, VIC, Australia., The Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia., Department of Psychiatry, Vrije Universiteit University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsPeter R Schofield - Neuroscience Research Australia, Sydney, NSW, Australia., School of Medical Sciences, University of New South Wales, Sydney, NSW, AustraliaRodrigo Secolin - Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Brazil., BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, BrazilChin Yang Shapland - Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsLi Shen - Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USAJean Shin - The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Population Neuroscience & Developmental Neuroimaging, Bloorview Research Institute, University of Toronto, East York, ON, CanadaElena Shumskaya - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, NetherlandsIda E Sønderby - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayEmma Sprooten - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NetherlandsKatherine E Tansey - MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKAlexander Teumer - Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyAnbupalam Thalamuthu - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, AustraliaDiana Tordesillas-Gutiérrez - Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain., Centro Investigacion Biomedica en Red Salud Mental, Santander, SpainJessica A Turner - Department of Psychology, Georgia State University, Atlanta, GA, USA., Mind Research Network, Albuquerque, NM, USAAnne Uhlmann - Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa., Department of Psychiatry, University of Vermont, Burlington, VT, USACostanza Ludovica Vallerga - Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, AustraliaDennis van der Meer - NORMENT, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, NetherlandsMarjolein M. J van Donkelaar - Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsLiza van Eijk - School of Psychology, University of Queensland, Brisbane, QLD, Australia., Queensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaTheo G. M van Erp - Department of Psychiatry and Human Behavior, School of Medicine University of California, Irvine, Irvine, CA, USANeeltje E. M van Haren - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam, NetherlandsDaan van Rooij - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, NetherlandsMarie-José van Tol - Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsJan H Veldink - Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsEllen Verhoef - Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsEsther Walton - Department of Psychology, Georgia State University, Atlanta, GA, USA., MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, Bristol, UK., Department of Psychology, University of Bath, Bath, UKMingyuan Wang - Research Division, Institute of Mental Health, Singapore, SingaporeYunpeng Wang - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayJoanna M Wardlaw - Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UKWei Wen - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, AustraliaLars T Westlye - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Department of Psychology, University of Oslo, Oslo, NorwayChristopher D Whelan - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, IrelandStephanie H Witt - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyKatharina Wittfeld - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., German Center for Neurodegenerative Diseases Rostock/Greifswald, Greifswald, GermanyChristiane Wolf - Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, GermanyThomas Wolfers - Department of Human Genetics, Radboud University Medical Center, Nijmegen, NetherlandsJing Qin Wu - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, AustraliaClarissa L Yasuda - BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Department of Neurology, FCM, UNICAMP, Campinas, BrazilDario Zaremba - Department of Psychiatry, University of Münster, Münster, GermanyZuo Zhang - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKMarcel P Zwiers - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, Netherlands., Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, NetherlandsEric Artiges - INSERM Unit 1000 - Neuroimaging & Psychiatry, Paris Saclay University, Gif sur Yvette, FranceAmelia A Assareh - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, AustraliaRosa Ayesa-Arriola - Centro Investigacion Biomedica en Red Salud Mental, Santander, Spain., Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Santander, SpainAysenil Belger - Duke UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA., Department of Psychiatry and Frank Porter Graham Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAChristine L Brandt - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayGregory G Brown - Department of Psychiatry, University of California San Diego, San Diego, CA, USA., VA San Diego Healthcare System, San Diego, CA, USASven Cichon - Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, GermanyJoanne E Curran - Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USAGareth E Davies - Avera Institute for Human Genetics, Sioux Falls, SD, USAMichelle F Dennis - Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham VA Medical Center, Durham, NC, USAFranziska Degenhardt - Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, GermanyBruno Dietsche - Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, GermanySrdjan Djurovic - Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., NORMENT, Department of Clinical Science, University of Bergen, Bergen, NorwayColin P Doherty - Department of Neurology, St James’s Hospital, Dublin, Ireland., Academic Unit of Neurology, TBSI, Dublin, Ireland., Future Neuro, Royal College of Surgeons in Ireland, Dublin, IrelandRyan Espiritu - Information Sciences Institute, University of Southern California, Los Angeles, CA, USADaniel Garijo - Information Sciences Institute, University of Southern California, Los Angeles, CA, USAYolanda Gil - Information Sciences Institute, University of Southern California, Los Angeles, CA, USAPenny A Gowland - Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UKRobert C Green - Brigham and Women’s Hospital, Boston, MA, USA., The Broad Institute, Boston, MA, USA., Harvard Medical School, Boston, MA, USAAlexander N Häusler - Center for Economics and Neuroscience, University of Bonn, Bonn, Germany., Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, GermanyWalter Heindel - Department of Clinical Radiology, University of Münster, Münster, GermanyBeng-Choon Ho - Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, USAWolfgang U Hoffmann - Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., German Center for Neurodegenerative Diseases Rostock/Greifswald, Greifswald, GermanyFlorian Holsboer - Max Planck Institute of Psychiatry, Munich, Germany., HMNC Holding GmbH, Munich, GermanyGeorg Homuth - University Medicine Greifswald, Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, Greifswald, GermanyNorbert Hosten - Institute of Diagnostic Radiology and Neuroradiology, Greifswald, GermanyClifford R Jack - Department of Radiology, Mayo Clinic, Rochester, MN, USAMiHyun Jang - Information Sciences Institute, University of Southern California, Los Angeles, CA, USAAndreas Jansen - Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Core-Unit Brainimaging, Faculty of Medicine, University of Marburg, Marburg, GermanyNathan A Kimbrel - Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham VA Medical Center, Durham, NC, USA., Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USAKnut Kolskår - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Department of Psychology, University of Oslo, Oslo, Norway., Sunnaas Rehabilitation Hospital HT, Nesodden, NorwaySanne Koops - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsAxel Krug - Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, GermanyKelvin O Lim - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAJurjen J Luykx - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., GGNet Mental Health, Apeldoorn, NetherlandsDaniel H Mathalon - Department of Psychiatry and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Mental Health Service 116d, Veterans Affairs San Francisco Healthcare System, San Francisco, CA, USAKaren A Mather - Neuroscience Research Australia, Sydney, NSW, Australia., Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, AustraliaVenkata S Mattay - Lieber Institute for Brain Development, Baltimore, MD, USA., Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Department of Radiology, Johns Hopkins University, Baltimore, MD, USASarah Matthews - MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, Bristol, UKJaqueline Mayoral Van Son - Centro Investigacion Biomedica en Red Salud Mental, Santander, Spain., Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Santander, SpainSarah C McEwen - Pacific Brain Health Center, Santa Monica, CA, USA., John Wayne Cancer Institute, Santa Monica, CA, USAIngrid Melle - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDerek W Morris - Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, IrelandBryon A Mueller - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USAMatthias Nauck - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., German Centre for Cardiovascular Research, Greifswald, GermanyJan E Nordvik - Sunnaas Rehabilitation Hospital HT, Nesodden, NorwayMarkus M Nöthen - Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, GermanyNils Opel - Department of Psychiatry, University of Münster, Münster, GermanyMarie-Laure Paillère Martinot - INSERM Unit 1000 - Neuroimaging & Psychiatry, Paris Saclay University, Gif sur Yvette, France., Child and Adolescent Psychiatry Department, APHP Pitié Salpêtrière Hospital, Paris, FranceG. Bruce Pike - Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, CanadaAdrian Preda - School of Medicine, University of California Irvine, Irvine, CA, USAErin B Quinlan - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKPaul E Rasser - Priority Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia., School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia., Priority Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, NSW, Australia., Hunter Medical Research Institute, Newcastle, NSW, AustraliaVarun Ratnakar - Information Sciences Institute, University of Southern California, Los Angeles, CA, USASimone Reppermund - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Department of Developmental Disability Neuropsychiatry, University of New South Wales, Sydney, NSW, AustraliaVidar M Steen - NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway., Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, NorwayPaul A Tooney - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Hunter Medical Research Institute, Newcastle, NSW, AustraliaFábio R Torres - Department of Medical Genetics and Genomic Medicine, School of Medical Sciences, University of Campinas - UNICAMP, Campinas, Brazil., BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, BrazilDick J Veltman - Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, NetherlandsJames T Voyvodic - Duke UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USARobert Whelan - School of Psychology, Trinity College Dublin, Dublin, IrelandTonya White - Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands., Department of Radiology, Erasmus University Medical Centre, Rotterdam, NetherlandsHidenaga Yamamori - Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, JapanHieab H. H Adams - Department of Epidemiology, Erasmus MC Medical Center, Rotterdam, Netherlands., Department of Radiology and Nuclear Medicine, Erasmus MC Medical Center, Rotterdam, Netherlands., Department of Clinical Genetics, Erasmus MC Medical Center, Rotterdam, NetherlandsJoshua C Bis - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAStephanie Debette - INSERM, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France., Department of Neurology, CHU de Bordeaux, Bordeaux, FranceCharles Decarli - Department of Neurology, University of California, Davis, Sacramento, CA, USAMyriam Fornage - Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USAVilmundur Gudnason - Icelandic Heart Association, Kopavogur, Iceland., Faculty of Medicine, University of Iceland, Reykjavik, IcelandEdith Hofer - Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, AustriaM. Arfan Ikram - Department of Epidemiology, Erasmus MC Medical Center, Rotterdam, NetherlandsLenore Launer - Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD, USAW. T Longstreth - Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USAOscar L Lopez - Department of Epidemiology, Erasmus MC Medical Center, Rotterdam, Netherlands., Medical Informatics, Erasmus MC Medical Center, Rotterdam, NetherlandsBernard Mazoyer - Neurodegeneratives Diseases Institute UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, FranceThomas H Mosley - MIND Center, University of Mississippi Medical Center, Jackson, MS, USAGennady V Roshchupkin - Department of Epidemiology, Erasmus MC Medical Center, Rotterdam, Netherlands., Department of Radiology and Nuclear Medicine, Erasmus MC Medical Center, Rotterdam, Netherlands., Medical Informatics, Erasmus MC Medical Center, Rotterdam, NetherlandsClaudia L Satizabal - Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Department of Epidemiology & Biostatistics, University of Texas Health Sciences Center, San Antonio, TX, USA., Department of Neurology, Boston University School of Medicine, Boston, MA, USAReinhold Schmidt - Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, AustriaSudha Seshadri - Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Framingham Heart Study and Department of Neurology, Boston University School of Medicine, Boston, MA, USAQiong Yang - Department of Biostatistics, Boston University School of Public Health, Boston, MA, USAMarina K. M Alvim - BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Department of Neurology, FCM, UNICAMP, Campinas, BrazilDavid Ames - Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, VIC, Australia., National Ageing Research Institute, Melbourne, VIC, AustraliaTim J Anderson - Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand., New Zealand Brain Research Institute, Christchurch, New Zealand., Brain Research New Zealand - Rangahau Roro Aotearoa, Christchurch, New Zealand., Department of Neurology, Canterbury District Health Board, Christchurch, New ZealandOle A Andreassen - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayAlejandro Arias-Vasquez - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Psychiatry, Radboud university medical center, Nijmegen, NetherlandsMark E Bastin - Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UKBernhard T Baune - Department of Psychiatry, University of Münster, Münster, Germany., Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia., Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, AustraliaJean C Beckham - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., VA Mid-Atlantic Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham, VA Healthcare System, Durham, NC, USAJohn Blangero - Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USADorret I Boomsma - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsHenry Brodaty - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, AustraliaHan G Brunner - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Clinical Genetics and School for Oncology and Developmental Biology (GROW), Maastricht University Medical Center, Maastricht, NetherlandsRandy L Buckner - Department of Psychology and Center for Brain Science, Harvard University, Boston, MA, USA., Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Department of Radiology, Massachusetts General Hospital, Boston, MA, USAJan K Buitelaar - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, Netherlands., Karakter Child and Adolescent Psychiatry University Center, Nijmegen, NetherlandsJuan R Bustillo - Department of Psychiatry, University of New Mexico, Albuquerque, NM, USAWiepke Cahn - Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsMurray J Cairns - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Priority Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia., Schizophrenia Research Institute, Randwick, NSW, AustraliaVince Calhoun - Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USAVaughan J Carr - School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Neuroscience Research Australia, Sydney, NSW, Australia., Department of Psychiatry, Monash University, Clayton, VIC, AustraliaXavier Caseras - MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UKSvenja Caspers - Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany., JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany., Institute for Anatomy I, Medical Faculty, Heinrich-Heine University, Düsseldorf, GermanyGianpiero L Cavalleri - Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., The SFI FutureNeuro Research Centre, Dublin, IrelandFernando Cendes - BRAINN - Brazilian Institute of Neuroscience and Neurotechnology, Campinas, Brazil., Department of Neurology, FCM, UNICAMP, Campinas, BrazilAiden Corvin - Department of Psychiatry, Trinity College Dublin, Dublin, IrelandBenedicto Crespo-Facorro - Centro Investigacion Biomedica en Red Salud Mental, Santander, Spain., Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria–IDIVAL, Santander, Spain., Hospital Universitario Virgen Del Rocio, IBiS, Universidad De Sevilla, Sevilla, SpainJohn C Dalrymple-Alford - New Zealand Brain Research Institute, Christchurch, New Zealand., Brain Research New Zealand - Rangahau Roro Aotearoa, Christchurch, New Zealand., School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New ZealandUdo Dannlowski - Department of Psychiatry, University of Münster, Münster, GermanyEco J. C de Geus - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsIan J Deary - Department of Psychology, University of Edinburgh, Edinburgh, UK., Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UKNorman Delanty - Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Future Neuro, Royal College of Surgeons in Ireland, Dublin, IrelandChantal Depondt - Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, BelgiumSylvane Desrivières - Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK., Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UKGary Donohoe - Centre for Neuroimaging and Cognitive Genomics, School of Psychology, National University of Ireland Galway, Galway, IrelandThomas Espeseth - NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Department of Psychology, University of Oslo, Oslo, NorwayGuillén Fernández - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen, NetherlandsSimon E Fisher - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsHerta Flor - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyAndreas J Forstner - Department of Biomedicine, University of Basel, Basel, Switzerland., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Department of Psychiatry (UPK), University of Basel, Basel, Switzerland., Centre for Human Genetics, University of Marburg, Marburg, GermanyClyde Francks - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, NetherlandsBarbara Franke - Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands., Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Department of Psychiatry, Radboud university medical center, Nijmegen, NetherlandsDavid C Glahn - Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, CT, USA., Tommy Fuss Center for Neuropsychiatric Disease Research, Boston Children’s Hospital and Department of Psychiatry, Harvard Medical School, Boston, MA, USARandy L Gollub - Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Department of Radiology, Massachusetts General Hospital, Boston, MA, USAHans J Grabe - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., German Center for Neurodegenerative Diseases Rostock/Greifswald, Greifswald, GermanyOliver Gruber - Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, GermanyAsta K Håberg - Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway., Department of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, NorwayAhmad R Hariri - Department of Psychology and Neuroscience, Duke University, Durham, NC, USACatharina A Hartman - University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, NetherlandsRyota Hashimoto - Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan., Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan., Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanAndreas Heinz - Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, GermanyFrans A Henskens - School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia., Health Behaviour Research Group, University of Newcastle, Callaghan, NSW, AustraliaManon H. J Hillegers - Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center-Sophia Children’s Hospital, Rotterdam, Netherlands., Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsPieter J Hoekstra - Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsAvram J Holmes - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Department of Psychology, Yale University, New Haven, CT, USAL. Elliot Hong - Maryland Psychiatry Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAWilliam D Hopkins - Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USAHilleke E Hulshoff Pol - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, NetherlandsTerry L Jernigan - Department of Radiology, University of California San Diego, San Diego, CA, USA., Department of Cognitive Science, University of California San Diego, San Diego, CA, USA., Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Center for Human Development, University of California San Diego, La Jolla, CA, USAErik G Jönsson - NORMENT - K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenRené S Kahn - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USAMartin A Kennedy - Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch, New ZealandTilo T. J Kircher - Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, GermanyPeter Kochunov - Maryland Psychiatry Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAJohn B. J Kwok - Neuroscience Research Australia, Sydney, NSW, Australia., School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Neurogenetics and Epigenetics, Brain and Mind Centre, The University of Sydney, Sydney, NSW, AustraliaStephanie Le Hellard - NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway., Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, NorwayCarmel M Loughland - School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia., Hunter New England Mental Health Service, Newcastle, NSW, AustraliaNicholas G Martin - Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaJean-Luc Martinot - INSERM Unit 1000 - Neuroimaging & Psychiatry, Paris Saclay University, Gif sur Yvette, FranceColm McDonald - Centre for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, IrelandKatie L McMahon - Herston Imaging Research Facility, School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaAndreas Meyer-Lindenberg - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyPatricia T Michie - School of Psychology, University of Newcastle, Callaghan, NSW, AustraliaRajendra A Morey - Duke UNC Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA., Mental Illness Research Education and Clinical Center for Post Deployment Mental Health, Durham VA Medical Center, Durham, NC, USABryan Mowry - Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Queensland Centre for Mental Health Research, University of Queensland, Brisbane, QLD, AustraliaLars Nyberg - Department of Integrative Medical Biology, Umeå University, Umeå, Sweden., Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden., Department of Radiation Sciences, Umeå University, Umeå, SwedenJaap Oosterlaan - Emma Children's Hospital Academic Medical Center, Amsterdam, Netherlands., Department of Pediatrics, Vrije Universiteit Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Clinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsRoel A Ophoff - Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USAChristos Pantelis - Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia., Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia., NorthWestern Mental Health, Sunshine Hospital, St Albans, VIC, AustraliaTomas Paus - Bloorview Research Institute, University of Toronto, Toronto, ON, Canada., Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada., Centre for Developing Brain, Child Mind Institute, New York, NY, USAZdenka Pausova - The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Department of Physiology, University of Toronto, Toronto, ON, CanadaBrenda W. J. H Penninx - Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit and GGZ inGeest, Amsterdam, NetherlandsTinca J. C Polderman - Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsDanielle Posthuma - Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Department of Clinical Genetics, Vrije Universiteit Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsMarcella Rietschel - Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyJoshua L Roffman - Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USALaura M Rowland - Maryland Psychiatry Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USAPerminder S Sachdev - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, AustraliaPhilipp G Sämann - Max Planck Institute of Psychiatry, Munich, GermanyUlrich Schall - Priority Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia., Hunter Medical Research Institute, Newcastle, NSW, AustraliaGunter Schumann - Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China., Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK., Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK., PONS Research Group, Department of Psychiatry and Psychotherapie, Charité Campus Mitte, Humboldt University Berlin, Berlin, Germany., Leibniz Institute for Neurobiology, Magdeburg, GermanyRodney J Scott - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Division of Molecular Medicine, John Hunter Hospital, New Lambton Heights, NSW, AustraliaKang Sim - General Psychiatry, Institute of Mental Health, Singapore, SingaporeSanjay M Sisodiya - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Chalfont Centre for Epilepsy, Chalfont-St-Peter, UKJordan W Smoller - Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Stanley Center for Psychiatric Research, Broad Institute, Boston, MA, USAIris E Sommer - Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Department of Medical and Biological Psychology, University of Bergen, Bergen, NorwayBeate St Pourcain - Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands., Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands., MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, Bristol, UKDan J Stein - Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., MRC Unit on Risk & Resilience in Mental Disorders, University of Cape Town, Cape Town, South AfricaArthur W Toga - Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USAJulian N Trollor - Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia., Department of Developmental Disability Neuropsychiatry, University of New South Wales, Sydney, NSW, AustraliaNic J. A Van der Wee - Department of Psychiatry, Leiden University Medical Center, Leiden, NetherlandsDennis van ’t Ent - Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, NetherlandsHenry Völzke - Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyHenrik Walter - Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyBernd Weber - Center for Economics and Neuroscience, University of Bonn, Bonn, Germany., Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, GermanyDaniel R Weinberger - Lieber Institute for Brain Development, Baltimore, MD, USA., Psychiatry, Neurology, Neuroscience, Genetics, Johns Hopkins University, Baltimore, MD, USAMargaret J Wright - Queensland Brain Institute, University of Queensland, St Lucia, QLD, Australia., Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, AustraliaJuan Zhou - Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke–National University of Singapore Medical School, Singapore, SingaporeJason L Stein - Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAPaul M Thompson - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USASarah E Medland - Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., School of Psychology, University of Queensland, Brisbane, QLD, Australia., Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.367(6484), pp.eaay6690-Grasby , K L , Jahanshad , N , Painter , J N , Colodro-conde , L , Bralten , J , Hibar , D P , Lind , P A , Pizzagalli , F , Ching , C R K , Mcmahon , M A B , Shatokhina , N , Zsembik , L C P , Thomopoulos , S I , Zhu , A H , Strike , L T , Agartz , I , Alhusaini , S , Almeida , M A A , Alnæs , D , Amlien , I K , Andersson , M , Ard , T , Armstrong , N J , Ashley-koch , A , Atkins , J R , Bernard , M , Brouwer , R M , Buimer , E E L , Bülow , R , Bürger , C , Cannon , D M , Chakravarty , M , Chen , Q , Cheung , J W , Couvy-duchesne , B , Dale , A M , Dalvie , S , De Araujo , T K , De Zubicaray , G I , De Zwarte , S M C , Den Braber , A , Doan , N T , Dohm , K , Ehrlich , S , Engelbrecht , H , Erk , S , Fan , C C , Fedko , I O , Foley , S F , Ford , J M , Fukunaga , M , Garrett , M E , Ge , T , Giddaluru , S , Goldman , A L , Green , M J , Groenewold , N A , Grotegerd , D , Gurholt , T P , Gutman , B A , Hansell , N K , Harris , M A , Harrison , M B , Haswell , C C , Hauser , M , Herms , S , Heslenfeld , D J , Ho , N F , Hoehn , D , Hoffmann , P , Holleran , L , Hoogman , M , Hottenga , J , Ikeda , M , Janowitz , D , Jansen , I E , Jia , T , Jockwitz , C , Kanai , R , Karama , S , Kasperaviciute , D , Kaufmann , T , Kelly , S , Kikuchi , M , Klein , M , Knapp , M , Knodt , A R , Krämer , B , Lam , M , Lancaster , T M , Lee , P H , Lett , T A , Lewis , L B , Lopes-cendes , I , Luciano , M , Macciardi , F , Marquand , A F , Mathias , S R , Melzer , T R , Milaneschi , Y , Mirza-schreiber , N , Moreira , J C V , Mühleisen , T W , Müller-myhsok , B , Najt , P , Nakahara , S , Nho , K , Olde Loohuis , L M , Orfanos , D P , Pearson , J F , Pitcher , T L , Pütz , B , Quidé , Y , Ragothaman , A , Rashid , F M , Reay , W R , Redlich , R , Reinbold , C S , Repple , J , Richard , G , Riedel , B C , Risacher , S L , Rocha , C S , Mota , N R , Salminen , L , Saremi , A , Saykin , A J , Schlag , F , Schmaal , L , Schofield , P R , Secolin , R , Shapland , C Y , Shen , L , Shin , J , Shumskaya , E , Sønderby , I E , Sprooten , E , Tansey , K E , Teumer , A , Thalamuthu , A , Tordesillas-gutiérrez , D , Turner , J A , Uhlmann , A , Vallerga , C L , Van Der Meer , D , Van Donkelaar , M M J , Van Eijk , L , Van Erp , T G M , Van Haren , N E M , Van Rooij , D , Van Tol , M , Veldink , J H , Verhoef , E , Walton , E , Wang , M , Wang , Y , Wardlaw , J M , Wen , W , Westlye , L T , Whelan , C D , Witt , S H , Wittfeld , K , Wolf , C , Wolfers , T , Wu , J Q , Yasuda , C L , Zaremba , D , Zhang , Z , Zwiers , M P , Artiges , E , Assareh , A A , Ayesa-arriola , R , Belger , A , Brandt , C L , Brown , G G , Cichon , S , Curran , J E , Davies , G E , Degenhardt , F , Dennis , M F , Dietsche , B , Djurovic , S , Doherty , C P , Espiritu , R , Garijo , D , Gil , Y , Gowland , P A , Green , R C , Häusler , A N , Heindel , W , Ho , B , Hoffmann , W U , Holsboer , F , Homuth , G , Hosten , N , Jack , C R , Jang , M , Jansen , A , Kimbrel , N A , Kolskår , K , Koops , S , Krug , A , Lim , K O , Luykx , J J , Mathalon , D H , Mather , K A , Mattay , V S , Matthews , S , Mayoral Van Son , J , Mcewen , S C , Melle , I , Morris , D W , Mueller , B A , Nauck , M , Nordvik , J E , Nöthen , M M , O’leary , D S , Opel , N , Martinot , M P , Pike , G B , Preda , A , Quinlan , E B , Rasser , P E , Ratnakar , V , Reppermund , S , Steen , V M , Tooney , P A , Torres , F R , Veltman , D J , Voyvodic , J T , Whelan , R , White , T , Yamamori , H , Adams , H H H , Bis , J C , Debette , S , Decarli , C , Fornage , M , Gudnason , V , Hofer , E , Ikram , M A , Launer , L , Longstreth , W T , Lopez , O L , Mazoyer , B , Mosley , T H , Roshchupkin , G V , Satizabal , C L , Schmidt , R , Seshadri , S , Yang , Q , Alvim , M K M , Ames , D , Anderson , T J , Andreassen , O A , Arias-vasquez , A , Bastin , M E , Baune , B T , Beckham , J C , Blangero , J , Boomsma , D I , Brodaty , H , Brunner , H G , Buckner , R L , Buitelaar , J K , Bustillo , J R , Cahn , W , Cairns , M J , Calhoun , V , Carr , V J , Caseras , X , Caspers , S , Cavalleri , G L , Cendes , F , Corvin , A , Crespo-facorro , B , Dalrymple-alford , J C , Dannlowski , U , De Geus , E J C , Deary , I J , Delanty , N , Depondt , C , Desrivières , S , Donohoe , G , Espeseth , T , Fernández , G , Fisher , S E , Flor , H , Forstner , A J , Francks , C , Franke , B , Glahn , D C , Gollub , R L , Grabe , H J , Gruber , O , Håberg , A K , Hariri , A R , Hartman , C A , Hashimoto , R , Heinz , A , Henskens , F A , Hillegers , M H J , Hoekstra , P J , Holmes , A J , Hong , L E , Hopkins , W D , Hulshoff Pol , H E , Jernigan , T L , Jönsson , E G , Kahn , R S , Kennedy , M A , Kircher , T T J , Kochunov , P , Kwok , J B J , Le Hellard , S , Loughland , C M , Martin , N G , Martinot , J , Mcdonald , C , Mcmahon , K L , Meyer-lindenberg , A , Michie , P T , Morey , R A , Mowry , B , Nyberg , L , Oosterlaan , J , Ophoff , R A , Pantelis , C , Paus , T , Pausova , Z , Penninx , B W J H , Polderman , T J C , Posthuma , D , Rietschel , M , Roffman , J L , Rowland , L M , Sachdev , P S , Sämann , P G , Schall , U , Schumann , G , Scott , R J , Sim , K , Sisodiya , S M , Smoller , J W , Sommer , I E , St Pourcain , B , Stein , D J , Toga , A W , Trollor , J N , Van Der Wee , N J A , Van ’t Ent , D , Völzke , H , Walter , H , Weber , B , Weinberger , D R , Wright , M J , Zhou , J , Stein , J L , Thompson , P M & Medland , S E 2020 , ' The genetic architecture of the human cerebral cortex ' , Science , vol. 367 , no. 6484 , pp. eaay6690 . https://doi.org/10.1126/science.aay6690
- DOI
- 10.1126/science.aay6690
- PMID
- 32193296
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: U54 EB020403; DOI: 10.13039/100000002, name: National Institutes of Health, award: U54 EB020403; DOI: 10.13039/100000002, name: National Institutes of Health, award: R01EB006841; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: 5T32MH073526; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01MH118349; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R00MH102357; DOI: 10.13039/100000049, name: National Institute on Aging, award: U01 AG024904; DOI: 10.13039/100000049, name: National Institute on Aging, award: P30 AG010129; DOI: 10.13039/100000049, name: National Institute on Aging, award: P30 AG010133; DOI: 10.13039/100000049, name: National Institute on Aging, award: R01 AG019771; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R00MH101367; DOI: 10.13039/100000049, name: National Institute on Aging, award: R03AG054936; DOI: 10.13039/100000092, name: U.S. National Library of Medicine, award: R01LM012535; DOI: 10.13039/100000098, name: NIH Clinical Center, award: R01MH084898-01A1; DOI: 10.13039/100000049, name: National Institute on Aging, award: T32AG058507; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: MH103790; DOI: 10.13039/100004431, name: European Commission Directorate-General for Research and Innovation, award: 785907; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: K01MH099431; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: APP1095127; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 386500; DOI: 10.13039/501100009287, name: NSW Health, award: N/A; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1051672; DOI: 10.13039/501100000265, name: UK Medical Research Council; DOI: 10.13039/501100000024, name: Canadian Institutes of Health Research; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 628386; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1105825; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 81801773; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 91630314; DOI: 10.13039/501100002338, name: Ministry of Education of the People's Republic of China, award: NO.B18015; DOI: 10.13039/501100003399, name: Science and Technology Commission of Shanghai Municipality, award: 16JC1420402; DOI: 10.13039/501100003399, name: Science and Technology Commission of Shanghai Municipality, award: 2018SHZDZX01; DOI: 10.13039/501100003399, name: Science and Technology Commission of Shanghai Municipality, award: 18PJ1400900; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1037196; DOI: 10.13039/501100006095, name: South-Eastern Norway Regional Health Authority, award: 2017112; name: The Research Council of Norway, award: 223273; name: KG Jebsen Foundation, award: SKGJ‐MED‐008; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1147644; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1121474; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1067137; DOI: 10.13039/501100001659, name: Deutsche Forschungsgemeinschaft, award: KI 588/14-2; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: APP1158127; DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: APP1103623; name: FAPESP - São Paulo Research Foundation - Brazil, award: 2013/07559-3; name: Tond Mohn Stiftelse, award: Career grant to SLH
- Language
- English
- Date published
- 03/20/2020
- Academic Unit
- Psychiatry
- Record Identifier
- 9984066114802771
Metrics
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