Journal article
The genetic basis of postzygotic reproductive isolation between Drosophila santomea and D. yakuba due to hybrid male sterility
Genetics (Austin), Vol.173(1), pp.225-233
05/2006
DOI: 10.1534/genetics.105.052985
PMCID: PMC1461443
PMID: 16510788
Abstract
A major unresolved challenge of evolutionary biology is to determine the nature of the allelic variants of "speciation genes": those alleles whose interaction produces inviable or infertile interspecific hybrids but does not reduce fitness in pure species. Here we map quantitative trait loci (QTL) affecting fertility of male hybrids between D. yakuba and its recently discovered sibling species, D. santomea. We mapped three to four X chromosome QTL and two autosomal QTL with large effects on the reduced fertility of D. yakuba and D. santomea backcross males. We observed epistasis between the X-linked QTL and also between the X and autosomal QTL. The X chromosome had a disproportionately large effect on hybrid sterility in both reciprocal backcross hybrids. However, the genetics of hybrid sterility differ between D. yakuba and D. santomea backcross males, both in terms of the magnitude of main effects and in the epistatic interactions. The QTL affecting hybrid fertility did not colocalize with QTL affecting sexual isolation in this species pair, but did colocalize with QTL affecting the marked difference in pigmentation between D. yakuba and D. santomea. These results provide the basis for future high-resolution mapping and ultimately, molecular cloning, of the interacting genes that contribute to hybrid sterility.
Details
- Title: Subtitle
- The genetic basis of postzygotic reproductive isolation between Drosophila santomea and D. yakuba due to hybrid male sterility
- Creators
- Amanda J Moehring - Department of Genetics, North Carolina State University, Raleigh 27695, USA. ajmoehring@gmail.comAna LlopartSusannah ElwynJerry A CoyneTrudy F C Mackay
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.173(1), pp.225-233
- Publisher
- United States
- DOI
- 10.1534/genetics.105.052985
- PMID
- 16510788
- PMCID
- PMC1461443
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Grant note
- P01 GM045344 / NIGMS NIH HHS GM45344 / NIGMS NIH HHS GM 58260 / NIGMS NIH HHS R01 GM058260 / NIGMS NIH HHS
- Language
- English
- Date published
- 05/2006
- Academic Unit
- Biology
- Record Identifier
- 9983991962702771
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