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The genetic reconstruction of BCG as a new immunotherapeutic tool
Journal article   Peer reviewed

The genetic reconstruction of BCG as a new immunotherapeutic tool

Michael A. O'Donnell
Trends in biotechnology (Regular ed.), Vol.15(12), pp.512-517
1997
DOI: 10.1016/S0167-7799(97)01134-7
PMID: 9418306

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Abstract

The bacillus of Calmette and Guérin (BCG), long appreciated for its role as a live vaccine for the prevention of tuberculosis, is undergoing a rebirth as a recombinant delivery vehicle for foreign antigens and bioactive proteins. Recombinant BCG causes long-lived specific humoral and cellular immunity and may ultimately prove to be a powerful and cost-effective new weapon against both infectious pathogens and certain cancers.

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